Format

Send to:

Choose Destination
    • Showing Current items.

    Ppp2r1b protein phosphatase 2, regulatory subunit A, beta [ Mus musculus (house mouse) ]

    Gene ID: 73699, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ppp2r1bprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit A, betaprovided by MGI
    Primary source
    MGI:MGI:1920949
    See related
    Ensembl:ENSMUSG00000032058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI790395; 2410091N08Rik
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 19.8), genital fat pad adult (RPKM 16.5) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp2r1b in Genome Data Viewer
    Location:
    9; 9 A5.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50767946..50810625)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50856896..50899325)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (50665040..50702334)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase) Neighboring gene predicted gene, 25558 Neighboring gene salt inducible kinase 2 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
    NP_001029257.1
    NP_001273482.1
    NP_082890.2
    XP_006510704.3
    XP_006510705.3
    XP_036011230.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034085.2NP_001029257.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a

      See identical proteins and their annotated locations for NP_001029257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 3. It encodes isoform a, which has a shorter and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC123614, AK161392
      Consensus CDS
      CCDS40625.1
      UniProtKB/TrEMBL
      Q3TTF6
      Related
      ENSMUSP00000034560.8, ENSMUST00000034560.14
      Conserved Domains (2) summary
      COG1413
      Location:227474
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:257281
      HEAT; HEAT repeat [structural motif]
    2. NM_001286553.1NP_001273482.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (c).
      Source sequence(s)
      AC123614, AK077158, AK136106, AK161392
      Consensus CDS
      CCDS72232.1
      UniProtKB/TrEMBL
      G3UWS4, Q3TTF6, Q8BIX1
      Related
      ENSMUSP00000133404.2, ENSMUST00000174628.8
      Conserved Domains (4) summary
      pfam02985
      Location:295325
      HEAT; HEAT repeat
      pfam13513
      Location:191240
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:217315
      HEAT_2; HEAT repeats
      sd00044
      Location:257281
      HEAT; HEAT repeat [structural motif]
    3. NM_028614.3NP_082890.2  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b

      See identical proteins and their annotated locations for NP_082890.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' structure and contains a 3' terminal exon which extends past a splice site that is used in variant 3. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC123614, AK010754, AK077158, AK136106, BC056218, BM932667, BY687256, CX566645
      Consensus CDS
      CCDS40626.1
      UniProtKB/Swiss-Prot
      Q7TNP2
      UniProtKB/TrEMBL
      Q8BIX1
      Related
      ENSMUSP00000110080.3, ENSMUST00000114437.9
      Conserved Domains (2) summary
      sd00044
      Location:257281
      HEAT; HEAT repeat [structural motif]
      cl26104
      Location:227474
      HEAT_2; HEAT repeats

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      50767946..50810625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510641.5XP_006510704.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

      Related
      ENSMUSP00000135525.2, ENSMUST00000176798.8
      Conserved Domains (3) summary
      COG1413
      Location:325572
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:355379
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:276306
      HEAT; HEAT repeat
    2. XM_006510642.5XP_006510705.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

      Conserved Domains (3) summary
      COG1413
      Location:325572
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:355379
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:276306
      HEAT; HEAT repeat
    3. XM_036155337.1XP_036011230.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3

      Conserved Domains (2) summary
      COG1413
      Location:2246
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:6690
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_001779023.3 RNA Sequence

    2. XR_001779024.3 RNA Sequence

    Support Center