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    Atg16l2 autophagy related 16-like 2 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 73683, updated on 25-Nov-2021

    Summary

    Official Symbol
    Atg16l2provided by MGI
    Official Full Name
    autophagy related 16-like 2 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1920933
    See related
    Ensembl:ENSMUSG00000047767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410118P20Rik
    Expression
    Ubiquitous expression in spleen adult (RPKM 5.6), thymus adult (RPKM 4.5) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Atg16l2 in Genome Data Viewer
    Location:
    7; 7 E2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100935521..100951474, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101286325..101302267, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (108438130..108450602, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene FCH and double SH3 domains 2 Neighboring gene uncharacterized LOC115486538 Neighboring gene predicted gene, 50587 Neighboring gene START domain containing 10 Neighboring gene predicted gene 20476 Neighboring gene predicted gene, 35219 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Chemically induced (ENU) (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    NOT involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative stranded viral RNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative stranded viral RNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein lipidation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Atg12-Atg5-Atg16 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Atg12-Atg5-Atg16 complex ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein Atg16l2
    Names
    APG16-like 2
    Atg16L2 alpha
    Atg16L2 beta
    autophagy related 16 like 2
    autophagy-related 16-like 2 alpha
    autophagy-related 16-like 2 beta
    autophagy-related protein 16-2
    mFLJ00012 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111111.1NP_001104581.1  protein Atg16l2

      See identical proteins and their annotated locations for NP_001104581.1

      Status: VALIDATED

      Source sequence(s)
      AK010773, BC060054, BP767155
      Consensus CDS
      CCDS52329.1
      UniProtKB/Swiss-Prot
      Q6KAU8
      UniProtKB/TrEMBL
      G9M4M8
      Related
      ENSMUSP00000112500.2, ENSMUST00000120267.9
      Conserved Domains (6) summary
      COG2319
      Location:327622
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:335622
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08614
      Location:20207
      ATG16; Autophagy protein 16 (ATG16)
      pfam16034
      Location:21198
      JAKMIP_CC3; JAKMIP CC3 domain
      sd00039
      Location:345382
      7WD40; WD40 repeat [structural motif]
      cl02193
      Location:109196
      VirB5_like; VirB5 protein family

    RNA

    1. NR_152152.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in several internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC107638
      Related
      ENSMUST00000139609.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100935521..100951474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508225.5XP_006508288.1  protein Atg16l2 isoform X1

      Conserved Domains (3) summary
      cd00200
      Location:338539
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:348385
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59231
      ATG16; Autophagy protein 16 (ATG16)
    2. XM_006508231.5XP_006508294.1  protein Atg16l2 isoform X8

      Conserved Domains (3) summary
      cd00200
      Location:359560
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:369406
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59231
      ATG16; Autophagy protein 16 (ATG16)
    3. XM_006508226.5XP_006508289.1  protein Atg16l2 isoform X3

      See identical proteins and their annotated locations for XP_006508289.1

      Related
      ENSMUSP00000113320.2, ENSMUST00000122116.8
      Conserved Domains (3) summary
      cd00200
      Location:338625
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:348385
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59231
      ATG16; Autophagy protein 16 (ATG16)
    4. XM_036153476.1XP_036009369.1  protein Atg16l2 isoform X5

      Conserved Domains (3) summary
      cd00200
      Location:316517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:326363
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59231
      ATG16; Autophagy protein 16 (ATG16)
    5. XM_036153475.1XP_036009368.1  protein Atg16l2 isoform X2

      Conserved Domains (3) summary
      cd00200
      Location:337538
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:347384
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59231
      ATG16; Autophagy protein 16 (ATG16)
    6. XM_011241916.4XP_011240218.1  protein Atg16l2 isoform X6

      Conserved Domains (3) summary
      cd00200
      Location:359560
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:369406
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59231
      ATG16; Autophagy protein 16 (ATG16)
    7. XM_006508227.5XP_006508290.1  protein Atg16l2 isoform X4

      Conserved Domains (3) summary
      cd00200
      Location:359616
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:369406
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:59231
      ATG16; Autophagy protein 16 (ATG16)
    8. XM_036153477.1XP_036009370.1  protein Atg16l2 isoform X9

      Conserved Domains (3) summary
      cd00200
      Location:204405
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:214251
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:197
      ATG16; Autophagy protein 16 (ATG16)
    9. XM_006508228.3XP_006508291.1  protein Atg16l2 isoform X7

      See identical proteins and their annotated locations for XP_006508291.1

      Conserved Domains (4) summary
      COG3064
      Location:2208
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
      cd00200
      Location:225426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:235272
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:197
      ATG16; Autophagy protein 16 (ATG16)
    10. XM_030243023.2XP_030098883.1  protein Atg16l2 isoform X9

      Conserved Domains (3) summary
      cd00200
      Location:204405
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:214251
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:197
      ATG16; Autophagy protein 16 (ATG16)
    11. XM_011241918.3XP_011240220.1  protein Atg16l2 isoform X7

      See identical proteins and their annotated locations for XP_011240220.1

      Conserved Domains (4) summary
      COG3064
      Location:2208
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
      cd00200
      Location:225426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:235272
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:197
      ATG16; Autophagy protein 16 (ATG16)
    12. XM_030243022.2XP_030098882.1  protein Atg16l2 isoform X7

      Conserved Domains (4) summary
      COG3064
      Location:2208
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
      cd00200
      Location:225426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:235272
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:197
      ATG16; Autophagy protein 16 (ATG16)
    13. XM_006508230.3XP_006508293.1  protein Atg16l2 isoform X7

      See identical proteins and their annotated locations for XP_006508293.1

      Conserved Domains (4) summary
      COG3064
      Location:2208
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
      cd00200
      Location:225426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:235272
      7WD40; WD40 repeat [structural motif]
      pfam08614
      Location:197
      ATG16; Autophagy protein 16 (ATG16)

    RNA

    1. XR_003946569.2 RNA Sequence

    2. XR_003946571.2 RNA Sequence

    3. XR_004934191.1 RNA Sequence

    4. XR_378274.5 RNA Sequence

    5. XR_004934190.1 RNA Sequence

    6. XR_001778004.3 RNA Sequence

    7. XR_004934192.1 RNA Sequence

    8. XR_003946570.2 RNA Sequence

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