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    Trmt11 tRNA methyltransferase 11 [ Mus musculus (house mouse) ]

    Gene ID: 73681, updated on 23-Jun-2021

    Summary

    Official Symbol
    Trmt11provided by MGI
    Official Full Name
    tRNA methyltransferase 11provided by MGI
    Primary source
    MGI:MGI:1920931
    See related
    Ensembl:ENSMUSG00000019792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW213713; 2410075D05Rik; 3110045I18Rik
    Expression
    Broad expression in liver E14 (RPKM 1.8), CNS E11.5 (RPKM 1.6) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Trmt11 in Genome Data Viewer
    Location:
    10; 10 A4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30410218..30477598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30534225..30602149, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (30254031..30320555, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40622 Neighboring gene predicted gene, 22623 Neighboring gene predicted gene, 20300 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene nuclear receptor coactivator 7 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA (guanine-N2-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    tRNA (guanine(10)-N2)-methyltransferase homolog
    Names
    tRNA guanosine-2'-O-methyltransferase TRM11 homolog
    tRNA methyltransferase 11 homolog
    NP_001345735.1
    NP_082880.2
    XP_006512940.1
    XP_006512943.1
    XP_030101177.1
    XP_030101179.1
    XP_030101180.1
    XP_036011940.1
    XP_036011941.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358806.1NP_001345735.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153899, AK010722, AK032943, BG083636, BY259542
      Conserved Domains (1) summary
      COG1041
      Location:2173
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    2. NM_028604.3NP_082880.2  tRNA (guanine(10)-N2)-methyltransferase homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153899, AK010722, AK032943, BG083636, BY259542
      Consensus CDS
      CCDS23763.1
      UniProtKB/Swiss-Prot
      Q9CWH5
      UniProtKB/TrEMBL
      E9QKG3
      Related
      ENSMUSP00000019927.7, ENSMUST00000019927.7
      Conserved Domains (2) summary
      COG1041
      Location:9398
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:190321
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      30410218..30477598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512877.4XP_006512940.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X1

      Conserved Domains (1) summary
      COG1041
      Location:9346
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    2. XM_030245319.2XP_030101179.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X5

      Conserved Domains (1) summary
      COG1041
      Location:2173
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    3. XM_006512880.5XP_006512943.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X4

      Conserved Domains (1) summary
      COG1041
      Location:1200
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    4. XM_030245317.2XP_030101177.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X3

      Conserved Domains (1) summary
      COG1041
      Location:5330
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    5. XM_030245320.2XP_030101180.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X5

      Conserved Domains (1) summary
      COG1041
      Location:2173
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    6. XM_036156047.1XP_036011940.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X2

      Conserved Domains (1) summary
      COG1041
      Location:7335
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    7. XM_036156048.1XP_036011941.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X5

      Conserved Domains (1) summary
      COG1041
      Location:2173
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
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