U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    UGT2B4 UDP glucuronosyltransferase family 2 member B4 [ Homo sapiens (human) ]

    Gene ID: 7363, updated on 27-Nov-2024

    Summary

    Official Symbol
    UGT2B4provided by HGNC
    Official Full Name
    UDP glucuronosyltransferase family 2 member B4provided by HGNC
    Primary source
    HGNC:HGNC:12553
    See related
    Ensembl:ENSG00000156096 MIM:600067; AllianceGenome:HGNC:12553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HLUG25; UDPGTH1; UGT2B11; UDPGT2B4; UDPGTh-1
    Summary
    Enables glucuronosyltransferase activity. Involved in cellular glucuronidation and estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward liver (RPKM 259.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See UGT2B4 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69480165..69526014, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (72814975..72860844, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70345883..70391732, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 2 member B7 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B24, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:70333407-70334146 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:70348366-70348559 Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene 7 Neighboring gene MPRA-validated peak5054 silencer Neighboring gene UDP glucuronosyltransferase family 2 member B7 pseudogene Neighboring gene MPRA-validated peak5055 silencer Neighboring gene UDP glucuronosyltransferase family 2 member A2 Neighboring gene UDP glucuronosyltransferase family 2 member A1 complex locus

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables retinoic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular glucuronidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in estrogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    UDP-glucuronosyltransferase 2B4
    Names
    UDP glucuronosyltransferase 2 family, polypeptide B4
    UDP-glucuronyltransferase, family 2, beta-4
    UDPGT 2B4
    hyodeoxycholic acid
    hyodeoxycholic acid-specific UDPGT
    NP_001284544.1
    NP_001284545.1
    NP_066962.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297615.2NP_001284544.1  UDP-glucuronosyltransferase 2B4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001284544.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF064200, AJ005162, AY529122, BX494777
      Consensus CDS
      CCDS75137.1
      Related
      ENSP00000421290.1, ENST00000512583.5
      Conserved Domains (2) summary
      pfam00201
      Location:24363
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
      cl10013
      Location:8368
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    2. NM_001297616.2NP_001284545.1  UDP-glucuronosyltransferase 2B4 isoform 3

      See identical proteins and their annotated locations for NP_001284545.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF064200, AK300084
      UniProtKB/Swiss-Prot
      P06133
      Conserved Domains (2) summary
      PHA03392
      Location:133376
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:15388
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    3. NM_021139.3NP_066962.2  UDP-glucuronosyltransferase 2B4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_066962.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF064200, BC026264, Y00317
      Consensus CDS
      CCDS43234.1
      UniProtKB/Swiss-Prot
      A6NCP7, B4DT75, G5E9X8, O60731, O60867, O75614, P06133, P36538, Q1HBF9, Q6QQX7
      Related
      ENSP00000305221.6, ENST00000305107.7
      Conserved Domains (2) summary
      PHA03392
      Location:8512
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:24524
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      69480165..69526014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      72814975..72860844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)