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    UCP2 uncoupling protein 2 [ Homo sapiens (human) ]

    Gene ID: 7351, updated on 23-Nov-2023

    Summary

    Official Symbol
    UCP2provided by HGNC
    Official Full Name
    uncoupling protein 2provided by HGNC
    Primary source
    HGNC:HGNC:12518
    See related
    Ensembl:ENSG00000175567 MIM:601693; AllianceGenome:HGNC:12518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UCPH; BMIQ4; SLC25A8
    Summary
    Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 136.6), spleen (RPKM 105.7) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See UCP2 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (73974672..73983202, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (73903817..73912347, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73685717..73694247, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene proteasomal ATPase associated factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73637447-73637946 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:73643667-73643917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73647840-73648474 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73694725-73695225 Neighboring gene family with sequence similarity 91 member A1 pseudogene Neighboring gene DPPA4 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in C4-dicarboxylate transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-aspartate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adaptive thermogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lead ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in liver regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in malate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oxaloacetate(2-) transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphate ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in proton transmembrane transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to superoxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    dicarboxylate carrier SLC25A8
    Names
    mitochondrial uncoupling protein 2
    solute carrier family 25 member 8
    uncoupling protein 2 (mitochondrial, proton carrier)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011478.1 RefSeqGene

      Range
      5002..13173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381943.1NP_001368872.1  dicarboxylate carrier SLC25A8 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP003717
      Consensus CDS
      CCDS8228.1
      UniProtKB/Swiss-Prot
      P55851, Q4PJH8, Q53HM3
      Conserved Domains (1) summary
      pfam00153
      Location:112206
      Mito_carr; Mitochondrial carrier protein
    2. NM_001381944.1NP_001368873.1  dicarboxylate carrier SLC25A8 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP003717
      Consensus CDS
      CCDS8228.1
      UniProtKB/Swiss-Prot
      P55851, Q4PJH8, Q53HM3
      Conserved Domains (1) summary
      pfam00153
      Location:112206
      Mito_carr; Mitochondrial carrier protein
    3. NM_001381945.1NP_001368874.1  dicarboxylate carrier SLC25A8 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP003717
      Consensus CDS
      CCDS8228.1
      UniProtKB/Swiss-Prot
      P55851, Q4PJH8, Q53HM3
      Related
      ENSP00000312029.3, ENST00000310473.9
      Conserved Domains (1) summary
      pfam00153
      Location:112206
      Mito_carr; Mitochondrial carrier protein
    4. NM_001381947.1NP_001368876.1  dicarboxylate carrier SLC25A8 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP003717
      Consensus CDS
      CCDS8228.1
      UniProtKB/Swiss-Prot
      P55851, Q4PJH8, Q53HM3
      Conserved Domains (1) summary
      pfam00153
      Location:112206
      Mito_carr; Mitochondrial carrier protein
    5. NM_001381948.1NP_001368877.1  dicarboxylate carrier SLC25A8 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP003717
      Consensus CDS
      CCDS8228.1
      UniProtKB/Swiss-Prot
      P55851, Q4PJH8, Q53HM3
      Conserved Domains (1) summary
      pfam00153
      Location:112206
      Mito_carr; Mitochondrial carrier protein
    6. NM_001381949.1NP_001368878.1  dicarboxylate carrier SLC25A8 isoform b

      Status: REVIEWED

      Source sequence(s)
      AP003717
      Conserved Domains (1) summary
      pfam00153
      Location:10111
      Mito_carr; Mitochondrial carrier protein
    7. NM_001381950.1NP_001368879.1  dicarboxylate carrier SLC25A8 isoform c

      Status: REVIEWED

      Source sequence(s)
      AP003717
      Conserved Domains (1) summary
      pfam00153
      Location:10111
      Mito_carr; Mitochondrial carrier protein
    8. NM_003355.3NP_003346.2  dicarboxylate carrier SLC25A8 isoform a

      See identical proteins and their annotated locations for NP_003346.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP003717
      Consensus CDS
      CCDS8228.1
      UniProtKB/Swiss-Prot
      P55851, Q4PJH8, Q53HM3
      Related
      ENSP00000499695.1, ENST00000663595.2
      Conserved Domains (1) summary
      pfam00153
      Location:112206
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      73974672..73983202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      73903817..73912347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)