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    Iws1 IWS1, SUPT6 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 73473, updated on 23-Jun-2021

    Summary

    Official Symbol
    Iws1provided by MGI
    Official Full Name
    IWS1, SUPT6 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1920723
    See related
    Ensembl:ENSMUSG00000024384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AL117927; AW214353; 3000008H23; 1700069O15Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.3), whole brain E14.5 (RPKM 5.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Iws1 in Genome Data Viewer
    Location:
    18; 18 B1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32200377..32237384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32067326..32104331)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (32227388..32263985)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene myosin VIIB Neighboring gene predicted gene 16344 Neighboring gene predicted gene, 35010 Neighboring gene protein C Neighboring gene eukaryotic translation initiation factor pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of histone H3-K36 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein IWS1 homolog
    Names
    IWS1 homolog
    IWS1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173441.3NP_775617.1  protein IWS1 homolog

      See identical proteins and their annotated locations for NP_775617.1

      Status: VALIDATED

      Source sequence(s)
      AC127347
      Consensus CDS
      CCDS29115.1
      UniProtKB/Swiss-Prot
      Q8C1D8
      Related
      ENSMUSP00000025243.4, ENSMUST00000025243.5
      Conserved Domains (2) summary
      PHA02664
      Location:206317
      PHA02664; hypothetical protein; Provisional
      cl00146
      Location:475739
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      32200377..32237384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526292.5XP_006526355.1  protein IWS1 homolog isoform X2

      Conserved Domains (2) summary
      COG5271
      Location:3464
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cl00146
      Location:474738
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    2. XM_006526291.5XP_006526354.1  protein IWS1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A1D5RLV0
      Related
      ENSMUSP00000148514.2, ENSMUST00000212675.2
      Conserved Domains (2) summary
      COG5271
      Location:18462
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cl00146
      Location:475724
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    RNA

    1. XR_386017.4 RNA Sequence

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