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    Hbp1 high mobility group box transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 73389, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hbp1provided by MGI
    Official Full Name
    high mobility group box transcription factor 1provided by MGI
    Primary source
    MGI:MGI:894659
    See related
    Ensembl:ENSMUSG00000002996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C86454; BE629963; 1700058O05Rik; C330012F01Rik
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 23.0), ovary adult (RPKM 22.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hbp1 in Genome Data Viewer
    Location:
    12; 12 A3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31976449..32000529, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31926452..31950530, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (32611320..32635400, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 5 Neighboring gene predicted gene, 25913 Neighboring gene predicted gene, 35666 Neighboring gene protein kinase, cAMP dependent regulatory, type II beta Neighboring gene predicted gene, 53716 Neighboring gene predicted gene, 51992

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    HMG box-containing protein 1
    Names
    HMG box transcription factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361928.1NP_001348857.1  HMG box-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      CT010463
      Conserved Domains (2) summary
      smart00536
      Location:214340
      AXH; domain in Ataxins and HMG containing proteins
      cd01388
      Location:435506
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    2. NM_153198.3NP_694878.2  HMG box-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK132503, AK133127, CT010463
      Consensus CDS
      CCDS25867.2
      UniProtKB/Swiss-Prot
      Q8R316
      UniProtKB/TrEMBL
      E9Q1A8
      Related
      ENSMUSP00000131158.3, ENSMUST00000172314.9
      Conserved Domains (2) summary
      smart00536
      Location:224350
      AXH; domain in Ataxins and HMG containing proteins
      cd01388
      Location:445516
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    3. NM_177993.4NP_818774.2  HMG box-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AK028674, AK133127
      Consensus CDS
      CCDS25868.2
      UniProtKB/Swiss-Prot
      Q8R316
      UniProtKB/TrEMBL
      E9Q469
      Related
      ENSMUSP00000131983.3, ENSMUST00000167458.9
      Conserved Domains (2) summary
      smart00536
      Location:224350
      AXH; domain in Ataxins and HMG containing proteins
      cl00082
      Location:445474
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      31976449..32000529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157627.1XP_036013520.1  HMG box-containing protein 1 isoform X5

      Conserved Domains (2) summary
      cd01388
      Location:370441
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08517
      Location:190272
      AXH; Ataxin-1 and HBP1 module (AXH)
    2. XM_030246951.2XP_030102811.1  HMG box-containing protein 1 isoform X3

      Conserved Domains (2) summary
      smart00536
      Location:214340
      AXH; domain in Ataxins and HMG containing proteins
      cd01388
      Location:435506
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    3. XM_036157626.1XP_036013519.1  HMG box-containing protein 1 isoform X4

      Conserved Domains (2) summary
      cd01388
      Location:370441
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08517
      Location:190272
      AXH; Ataxin-1 and HBP1 module (AXH)
    4. XM_006515227.4XP_006515290.1  HMG box-containing protein 1 isoform X1

      Conserved Domains (2) summary
      smart00536
      Location:224350
      AXH; domain in Ataxins and HMG containing proteins
      cd01388
      Location:445516
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    5. XM_006515229.5XP_006515292.1  HMG box-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006515292.1

      Conserved Domains (2) summary
      smart00536
      Location:214340
      AXH; domain in Ataxins and HMG containing proteins
      cd01388
      Location:435506
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    6. XM_006515228.5XP_006515291.1  HMG box-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006515291.1

      Conserved Domains (2) summary
      smart00536
      Location:214340
      AXH; domain in Ataxins and HMG containing proteins
      cd01388
      Location:435506
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
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