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    UBC ubiquitin C [ Homo sapiens (human) ]

    Gene ID: 7316, updated on 17-Jun-2024

    Summary

    Official Symbol
    UBCprovided by HGNC
    Official Full Name
    ubiquitin Cprovided by HGNC
    Primary source
    HGNC:HGNC:12468
    See related
    Ensembl:ENSG00000150991 MIM:191340; AllianceGenome:HGNC:12468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMG20
    Summary
    This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 1559.8), gall bladder (RPKM 1270.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UBC in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (124911646..124914650, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (124916854..124919858, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125396192..125399196, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5067 Neighboring gene uncharacterized LOC105370050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7306 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25236 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:125351043-125352242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125369125-125369812 Neighboring gene CRISPRi-validated cis-regulatory element chr12.4732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7308 Neighboring gene RNA, U6 small nuclear 927, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9680 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125398493-125399450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5068 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:125400549-125401748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5070 Neighboring gene microRNA 5188 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:125405603-125406281 Neighboring gene tRNA-Ala (anticodon TGC) 3-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev is modified by polyubiquitination at Lys-33 and Lys-115; Lys-33 is the most efficient residue for branching of ubiquitin chains PubMed
    Tat tat HIV-1 Tat is ubiquitinated on Lys71 by Hdm2 in conjunction with ubiquitin-activating enzyme E1 and ubiquitin-conjugating enzyme E2D 1 (UbcH5) PubMed
    Vif vif HIV-1 Vif-induced G2 accumulation requires a Cul5-based E3 ligase, but is independent of APOBEC3D/E, F, and G expression. Overexpression of ubiquitin(K48R) abolishes Vif-induced G2 accumulation PubMed
    Vpr vpr A di-Ub(K48)-hHR23A-Vpr ternary complex is formed with Lys-48-linked di-ubiquitin binding to the UBA1 domain in the Vpr-hHR23A complex PubMed
    vpr The C-terminal domain or the R90 residue of HIV-1 Vpr are important for Vpr-mediated IL-12 degradation via ubiquitin-dependent pathway PubMed
    capsid gag Monoubiquitinated forms of the HIV-1 matrix (MA), capsid (CA), and nucleocapsid (NC) proteins are detected in mature virus particles PubMed
    matrix gag Monoubiquitinated forms of the HIV-1 matrix (MA), capsid (CA), and nucleocapsid (NC) proteins are detected in mature virus particles PubMed
    nucleocapsid gag Monoubiquitinated forms of the HIV-1 matrix (MA), capsid (CA), and nucleocapsid (NC) proteins are detected in mature virus particles PubMed
    p1 gag HIV-1 p1 is mono- or di-ubiquitinated at levels comparable to those of the other HIV-2 Gag domains MA, CA, NC, and p6; cumulative replacement of all lysine residues in NC and p1 or in NC and p6 results in an accumulation of late budding structures PubMed
    p6 gag HIV-1 Gag PTAP mutant impairs the entry of Gag into the ESCRT pathway and leads to increased ubiquitination of Gag PubMed
    gag Ubiquitination of HIV-1 p6-Gag may be important for proper virus release from cells PubMed
    gag The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: SCARB1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in vesicle HDA PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027722.2 RefSeqGene

      Range
      5392..8396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021009.7NP_066289.3  polyubiquitin-C

      See identical proteins and their annotated locations for NP_066289.3

      Status: REVIEWED

      Source sequence(s)
      AK129749, BC093445
      Consensus CDS
      CCDS9260.1
      UniProtKB/Swiss-Prot
      P0CG48
      UniProtKB/TrEMBL
      L8B4M0, L8B4Z6
      Related
      ENSP00000344818.5, ENST00000339647.6
      Conserved Domains (1) summary
      cd01803
      Location:77152
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      124911646..124914650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      124916854..124919858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)