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    Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 [ Mus musculus (house mouse) ]

    Gene ID: 73086, updated on 5-Sep-2021

    Summary

    Official Symbol
    Rps6ka5provided by MGI
    Official Full Name
    ribosomal protein S6 kinase, polypeptide 5provided by MGI
    Primary source
    MGI:MGI:1920336
    See related
    Ensembl:ENSMUSG00000021180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSK; MSK1; RLPK; RLSK; MSPK1; AI854034; S6K-alpha-5; 3110005L17Rik; 6330404E13Rik
    Expression
    Broad expression in cerebellum adult (RPKM 5.5), CNS E18 (RPKM 4.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Rps6ka5 in Genome Data Viewer
    Location:
    12; 12 E
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100514692..100691693, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100548439..100725328, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (101787988..101963238, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene predicted gene, 53757 Neighboring gene predicted gene, 36375 Neighboring gene predicted gene 2614 Neighboring gene predicted gene, 40558 Neighboring gene predicted gene, 25801

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC28385

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in histone H2A-S1 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-S10 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-S10 phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in histone H3-S28 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-S28 phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in histone phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase alpha-5
    Names
    90 kDa ribosomal protein S6 kinase 5
    RSK-like protein kinase
    nuclear mitogen- and stress-activated protein kinase 1
    NP_001317631.1
    NP_705815.1
    XP_006516338.1
    XP_030102809.1
    XP_030102810.1
    XP_036013517.1
    XP_036013518.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330702.1NP_001317631.1  ribosomal protein S6 kinase alpha-5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC123705, AC159818, AK032316, AK160758, BQ174267, CX207283
      Consensus CDS
      CCDS88388.1
      UniProtKB/Swiss-Prot
      Q8C050
      UniProtKB/TrEMBL
      Q3TUH8
      Related
      ENSMUSP00000152481.2, ENSMUST00000222731.2
    2. NM_153587.3NP_705815.1  ribosomal protein S6 kinase alpha-5 isoform 1

      See identical proteins and their annotated locations for NP_705815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123705, AC159818, AK032316, AK160758, AY341873, BQ174267, CX207283
      Consensus CDS
      CCDS26107.1
      UniProtKB/Swiss-Prot
      Q8C050
      UniProtKB/TrEMBL
      Q3TUH8
      Related
      ENSMUSP00000042987.7, ENSMUST00000043599.7
      Conserved Domains (3) summary
      smart00220
      Location:48317
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14179
      Location:417791
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:47379
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      100514692..100691693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516275.5XP_006516338.1  ribosomal protein S6 kinase alpha-5 isoform X1

      Conserved Domains (2) summary
      cd14179
      Location:393702
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:34355
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036157624.1XP_036013517.1  ribosomal protein S6 kinase alpha-5 isoform X2

      Conserved Domains (2) summary
      cd14179
      Location:389698
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:47351
      PKc_like; Protein Kinases, catalytic domain
    3. XM_030246950.2XP_030102810.1  ribosomal protein S6 kinase alpha-5 isoform X3

      Conserved Domains (2) summary
      cd14179
      Location:199508
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:1161
      PKc_like; Protein Kinases, catalytic domain
    4. XM_036157625.1XP_036013518.1  ribosomal protein S6 kinase alpha-5 isoform X3

      Conserved Domains (2) summary
      cd14179
      Location:199508
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:1161
      PKc_like; Protein Kinases, catalytic domain
    5. XM_030246949.2XP_030102809.1  ribosomal protein S6 kinase alpha-5 isoform X3

      Conserved Domains (2) summary
      cd14179
      Location:199508
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:1161
      PKc_like; Protein Kinases, catalytic domain
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