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    Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 [ Mus musculus (house mouse) ]

    Gene ID: 73086, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rps6ka5provided by MGI
    Official Full Name
    ribosomal protein S6 kinase, polypeptide 5provided by MGI
    Primary source
    MGI:MGI:1920336
    See related
    Ensembl:ENSMUSG00000021180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSK1; RLPK; RLSK; MSPK1; AI854034; S6K-alpha-5; 3110005L17Rik; 6330404E13Rik
    Expression
    Broad expression in cerebellum adult (RPKM 5.5), CNS E18 (RPKM 4.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See Rps6ka5 in Genome Data Viewer
    Location:
    12; 12 E
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (100549778..100725395, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (101787988..101963238, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10432 Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene predicted gene, 36375 Neighboring gene predicted gene 2614 Neighboring gene predicted gene, 40558

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC28385

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    histone H2A-S1 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-S10 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-S10 phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    histone H3-S28 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-S28 phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase alpha-5
    Names
    90 kDa ribosomal protein S6 kinase 5
    RSK-like protein kinase
    nuclear mitogen- and stress-activated protein kinase 1
    NP_705815.1
    XP_006516337.1
    XP_006516338.1
    XP_006516339.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330702.1NP_001317631.1  ribosomal protein S6 kinase alpha-5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC123705, AC159818, AK032316, AK160758, BQ174267, CX207283
      UniProtKB/Swiss-Prot
      Q8C050
      UniProtKB/TrEMBL
      Q3TUH8
    2. NM_153587.3NP_705815.1  ribosomal protein S6 kinase alpha-5 isoform 1

      See identical proteins and their annotated locations for NP_705815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123705, AC159818, AK032316, AK160758, AY341873, BQ174267, CX207283
      Consensus CDS
      CCDS26107.1
      UniProtKB/Swiss-Prot
      Q8C050
      UniProtKB/TrEMBL
      Q3TUH8
      Related
      ENSMUSP00000042987.6, ENSMUST00000043599.6
      Conserved Domains (3) summary
      smart00220
      Location:48317
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14179
      Location:417791
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:47379
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      100549778..100725395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516275.3XP_006516338.1  ribosomal protein S6 kinase alpha-5 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:405662
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14179
      Location:393702
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:34355
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006516274.3XP_006516337.1  ribosomal protein S6 kinase alpha-5 isoform X1

      Related
      ENSMUSP00000152481.1, ENSMUST00000222731.1
      Conserved Domains (3) summary
      smart00220
      Location:48317
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14179
      Location:417726
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:47379
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006516276.3XP_006516339.1  ribosomal protein S6 kinase alpha-5 isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:211468
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14179
      Location:199508
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:1161
      PKc_like; Protein Kinases, catalytic domain
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