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    Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 [ Mus musculus (house mouse) ]

    Gene ID: 73086, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rps6ka5provided by MGI
    Official Full Name
    ribosomal protein S6 kinase, polypeptide 5provided by MGI
    Primary source
    MGI:MGI:1920336
    See related
    Ensembl:ENSMUSG00000021180 AllianceGenome:MGI:1920336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSK1; RLPK; RLSK; MSPK1; S6K-alpha-5; 3110005L17Rik; 6330404E13Rik
    Summary
    Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of DNA-templated transcription; and regulation of postsynapse organization. Located in nucleus. Orthologous to human RPS6KA5 (ribosomal protein S6 kinase A5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 5.5), CNS E18 (RPKM 4.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rps6ka5 in Genome Data Viewer
    Location:
    12 E; 12 50.81 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100514692..100691693, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100548439..100725328, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene STARR-positive B cell enhancer ABC_E7167 Neighboring gene predicted gene, 53757 Neighboring gene predicted gene, 36375 Neighboring gene STARR-seq mESC enhancer starr_33048 Neighboring gene STARR-positive B cell enhancer ABC_E1450 Neighboring gene STARR-seq mESC enhancer starr_33055 Neighboring gene STARR-positive B cell enhancer mm9_chr12:101842850-101843151 Neighboring gene STARR-seq mESC enhancer starr_33059 Neighboring gene STARR-positive B cell enhancer ABC_E1451 Neighboring gene STARR-positive B cell enhancer ABC_E8499 Neighboring gene STARR-seq mESC enhancer starr_33061 Neighboring gene predicted gene 2614 Neighboring gene predicted gene, 40558 Neighboring gene predicted gene, 25801

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC28385

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AS1 kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3S10 kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3S28 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3S28 kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-translational protein modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase alpha-5
    Names
    90 kDa ribosomal protein S6 kinase 5
    RSK-like protein kinase
    nuclear mitogen- and stress-activated protein kinase 1
    NP_001317631.1
    NP_705815.1
    XP_006516338.1
    XP_030102809.1
    XP_030102810.1
    XP_036013517.1
    XP_036013518.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330702.1NP_001317631.1  ribosomal protein S6 kinase alpha-5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC123705, AC159818, AK032316, AK160758, BQ174267, CX207283
      Consensus CDS
      CCDS88388.1
      UniProtKB/Swiss-Prot
      Q8C050
      UniProtKB/TrEMBL
      Q3TUH8
      Related
      ENSMUSP00000152481.2, ENSMUST00000222731.2
    2. NM_153587.3NP_705815.1  ribosomal protein S6 kinase alpha-5 isoform 1

      See identical proteins and their annotated locations for NP_705815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123705, AC159818, AK032316, AK160758, AY341873, BQ174267, CX207283
      Consensus CDS
      CCDS26107.1
      UniProtKB/Swiss-Prot
      Q8C050, Q8CI92
      Related
      ENSMUSP00000042987.7, ENSMUST00000043599.7
      Conserved Domains (3) summary
      smart00220
      Location:48317
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14179
      Location:417791
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:47379
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      100514692..100691693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516275.5XP_006516338.1  ribosomal protein S6 kinase alpha-5 isoform X1

      Conserved Domains (2) summary
      cd14179
      Location:393702
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:34355
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036157624.1XP_036013517.1  ribosomal protein S6 kinase alpha-5 isoform X2

      Conserved Domains (2) summary
      cd14179
      Location:389698
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:47351
      PKc_like; Protein Kinases, catalytic domain
    3. XM_030246950.2XP_030102810.1  ribosomal protein S6 kinase alpha-5 isoform X3

      UniProtKB/TrEMBL
      Q3TUH8
      Conserved Domains (2) summary
      cd14179
      Location:199508
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:1161
      PKc_like; Protein Kinases, catalytic domain
    4. XM_036157625.1XP_036013518.1  ribosomal protein S6 kinase alpha-5 isoform X3

      UniProtKB/TrEMBL
      Q3TUH8
      Conserved Domains (2) summary
      cd14179
      Location:199508
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:1161
      PKc_like; Protein Kinases, catalytic domain
    5. XM_030246949.2XP_030102809.1  ribosomal protein S6 kinase alpha-5 isoform X3

      UniProtKB/TrEMBL
      Q3TUH8
      Conserved Domains (2) summary
      cd14179
      Location:199508
      STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
      cl21453
      Location:1161
      PKc_like; Protein Kinases, catalytic domain