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    Pmpcb peptidase (mitochondrial processing) beta [ Mus musculus (house mouse) ]

    Gene ID: 73078, updated on 2-Nov-2024

    Summary

    Official Symbol
    Pmpcbprovided by MGI
    Official Full Name
    peptidase (mitochondrial processing) betaprovided by MGI
    Primary source
    MGI:MGI:1920328
    See related
    Ensembl:ENSMUSG00000029017 AllianceGenome:MGI:1920328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPPB; MPP11; MPPP52; 3110004O18Rik
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to contribute to metallopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrial inner membrane. Is expressed in several structures, including extraembryonic component; gallbladder; genitourinary system; gut gland; and nervous system. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 6. Orthologous to human PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 46.3), heart adult (RPKM 42.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pmpcb in Genome Data Viewer
    Location:
    5 A3; 5 9.97 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21942158..21962150)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21737160..21757152)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene BCL2-associated transcription factor 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6311 Neighboring gene VISTA enhancer mm1463 Neighboring gene STARR-positive B cell enhancer ABC_E11721 Neighboring gene predicted gene, 54323 Neighboring gene STARR-seq mESC enhancer starr_12576 Neighboring gene predicted gene 15715 Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mitochondrial processing peptidase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial-processing peptidase subunit beta
    Names
    P-52
    beta-MPP
    NP_001404726.1
    NP_082707.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417797.1NP_001404726.1  mitochondrial-processing peptidase subunit beta isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125313, AC125343
    2. NM_028431.2NP_082707.1  mitochondrial-processing peptidase subunit beta isoform 1 precursor

      See identical proteins and their annotated locations for NP_082707.1

      Status: VALIDATED

      Source sequence(s)
      AK013995
      Consensus CDS
      CCDS19106.1
      UniProtKB/Swiss-Prot
      Q9CXT8
      UniProtKB/TrEMBL
      Q3TET5
      Related
      ENSMUSP00000030882.6, ENSMUST00000030882.12
      Conserved Domains (1) summary
      COG0612
      Location:46478
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]

    RNA

    1. NR_184580.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125313, AC125343

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21942158..21962150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)