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    Pmpcb peptidase (mitochondrial processing) beta [ Mus musculus (house mouse) ]

    Gene ID: 73078, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pmpcbprovided by MGI
    Official Full Name
    peptidase (mitochondrial processing) betaprovided by MGI
    Primary source
    MGI:MGI:1920328
    See related
    Ensembl:ENSMUSG00000029017
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPP; MPPB; MPP11; MPPP52; 3110004O18Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 46.3), heart adult (RPKM 42.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pmpcb in Genome Data Viewer
    Location:
    5; 5 A3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21942143..21962150)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21737160..21757152)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (21242978..21262970)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene BCL2-associated transcription factor 1 pseudogene Neighboring gene VISTA enhancer mm1463 Neighboring gene predicted gene, 54323 Neighboring gene predicted gene 15715 Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein processing involved in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitochondrial-processing peptidase subunit beta
    Names
    P-52
    beta-MPP
    NP_082707.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028431.2NP_082707.1  mitochondrial-processing peptidase subunit beta precursor

      See identical proteins and their annotated locations for NP_082707.1

      Status: PROVISIONAL

      Source sequence(s)
      AK013995
      Consensus CDS
      CCDS19106.1
      UniProtKB/Swiss-Prot
      Q9CXT8
      Related
      ENSMUSP00000030882.6, ENSMUST00000030882.12
      Conserved Domains (3) summary
      COG0612
      Location:46478
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:68215
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:220404
      Peptidase_M16_C; Peptidase M16 inactive domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21942143..21962150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004942576.1 RNA Sequence

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