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    Glrx5 glutaredoxin 5 [ Mus musculus (house mouse) ]

    Gene ID: 73046, updated on 23-Jun-2021

    Summary

    Official Symbol
    Glrx5provided by MGI
    Official Full Name
    glutaredoxin 5provided by MGI
    Primary source
    MGI:MGI:1920296
    See related
    Ensembl:ENSMUSG00000021102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in the human gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 213.8), liver E14 (RPKM 197.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Glrx5 in Genome Data Viewer
    Location:
    12; 12 E
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104998877..105007170)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105032618..105040911)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (106270899..106279120)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing, nuclear envelope family member 3 Neighboring gene predicted gene, 31742 Neighboring gene small Cajal body-specific RNA 1 Neighboring gene microRNA 3069 Neighboring gene small nucleolar RNA host gene 10 Neighboring gene predicted gene, 46374 Neighboring gene predicted gene, 31884 Neighboring gene predicted gene, 31829

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 2310004O13Rik, 2900070E19Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation by [2Fe-2S] cluster transfer ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation by [4Fe-4S] cluster transfer ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutaredoxin-related protein 5, mitochondrial
    Names
    glutaredoxin 5 homolog
    monothiol glutaredoxin-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028419.3NP_082695.1  glutaredoxin-related protein 5, mitochondrial

      See identical proteins and their annotated locations for NP_082695.1

      Status: REVIEWED

      Source sequence(s)
      AK013761, CJ071975, CJ265616, CX243759
      Consensus CDS
      CCDS26154.1
      UniProtKB/Swiss-Prot
      Q80Y14
      Related
      ENSMUSP00000021522.4, ENSMUST00000021522.5
      Conserved Domains (1) summary
      cd03028
      Location:41131
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104998877..105007170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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