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    ZNF726 zinc finger protein 726 [ Homo sapiens (human) ]

    Gene ID: 730087, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF726provided by HGNC
    Official Full Name
    zinc finger protein 726provided by HGNC
    Primary source
    HGNC:HGNC:32462
    See related
    Ensembl:ENSG00000213967 AllianceGenome:HGNC:32462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF92P3
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See ZNF726 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23914886..23944714)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (24060450..24090278)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (24097688..24127516)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA 2 Neighboring gene uncharacterized LOC124904677 Neighboring gene zinc finger protein 726 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:24078454-24078954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:24078955-24079455 Neighboring gene uncharacterized LOC100505851 Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene Sharpr-MPRA regulatory regions 11764 and 11751 Neighboring gene Sharpr-MPRA regulatory region 3900

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 726
    Names
    zinc finger protein 92 pseudogene 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244038.2NP_001230967.1  zinc finger protein 726 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC011503, CN359557
      Consensus CDS
      CCDS59372.1
      UniProtKB/Swiss-Prot
      A6NNF4, M0R0X8, Q86Y87
      Related
      ENSP00000471516.1, ENST00000594466.6
      Conserved Domains (3) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:186612
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:371391
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001348687.2NP_001335616.1  zinc finger protein 726 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB593087, AC011503, CN359557
      Consensus CDS
      CCDS86738.1
      UniProtKB/TrEMBL
      F1T0F3, J3KNQ9
      Related
      ENSP00000461349.1, ENST00000575986.1
      Conserved Domains (1) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
    3. NM_001348688.2NP_001335617.1  zinc finger protein 726 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC011503
      Consensus CDS
      CCDS54241.1
      UniProtKB/TrEMBL
      E9PLI7
      Related
      ENSP00000433319.2, ENST00000525354.6
    4. NM_001348689.2NP_001335618.1  zinc finger protein 726 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC011503
      Consensus CDS
      CCDS86739.1
      UniProtKB/TrEMBL
      A0A8I5GK09
      Related
      ENSP00000432583.2, ENST00000531821.6
      Conserved Domains (1) summary
      smart00349
      Location:464
      KRAB; krueppel associated box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      23914886..23944714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      24060450..24090278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001190829.1: Suppressed sequence

      Description
      NM_001190829.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.