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    Thap12 THAP domain containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 72981, updated on 23-Jun-2021

    Summary

    Official Symbol
    Thap12provided by MGI
    Official Full Name
    THAP domain containing 12provided by MGI
    Primary source
    MGI:MGI:1920231
    See related
    Ensembl:ENSMUSG00000030753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; Da; Dap4; Prkrir; Rpkrir; 2900052B10Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.2), bladder adult (RPKM 15.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Thap12 in Genome Data Viewer
    Location:
    7; 7 E1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98352254..98367269)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (98703036..98718062)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (105851873..105866572)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene EMSY, BRCA2-interacting transcriptional repressor Neighboring gene predicted gene 15506 Neighboring gene putative uncharacterized protein FLJ37770 pseudogene Neighboring gene thymosin, beta 10 pseudogene Neighboring gene predicted gene, 33720

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC31389

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    52 kDa repressor of the inhibitor of the protein kinase
    Names
    58 kDa interferon-induced protein kinase-interacting protein
    P52rIPK
    THAP domain-containing protein 0
    THAP domain-containing protein 12
    interferon-inducible, double stranded RNA dependent inhibitor, protein-kinase
    p58IPK-interacting protein
    protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355114.1NP_001342043.1  52 kDa repressor of the inhibitor of the protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC111124
      Conserved Domains (2) summary
      pfam05699
      Location:498555
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:3155
      DUF4371; Domain of unknown function (DUF4371)
    2. NM_028410.2NP_082686.1  52 kDa repressor of the inhibitor of the protein kinase isoform 1

      See identical proteins and their annotated locations for NP_082686.1

      Status: VALIDATED

      Source sequence(s)
      AC111124
      Consensus CDS
      CCDS21474.1
      UniProtKB/Swiss-Prot
      Q9CUX1
      Related
      ENSMUSP00000033009.10, ENSMUST00000033009.16
      Conserved Domains (3) summary
      pfam05485
      Location:586
      THAP; THAP domain
      pfam05699
      Location:669726
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:152326
      DUF4371; Domain of unknown function (DUF4371)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      98352254..98367269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241915.4XP_011240217.1  52 kDa repressor of the inhibitor of the protein kinase isoform X1

      See identical proteins and their annotated locations for XP_011240217.1

      UniProtKB/Swiss-Prot
      Q9CUX1
      Conserved Domains (3) summary
      pfam05485
      Location:586
      THAP; THAP domain
      pfam05699
      Location:669726
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:152326
      DUF4371; Domain of unknown function (DUF4371)
    2. XM_036153467.1XP_036009360.1  52 kDa repressor of the inhibitor of the protein kinase isoform X2

      Conserved Domains (2) summary
      pfam05699
      Location:498555
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:3155
      DUF4371; Domain of unknown function (DUF4371)
    3. XM_006508224.5XP_006508287.1  52 kDa repressor of the inhibitor of the protein kinase isoform X2

      See identical proteins and their annotated locations for XP_006508287.1

      Conserved Domains (2) summary
      pfam05699
      Location:498555
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:3155
      DUF4371; Domain of unknown function (DUF4371)
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