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    RGPD6 RANBP2 like and GRIP domain containing 6 [ Homo sapiens (human) ]

    Gene ID: 729540, updated on 3-Apr-2024

    Summary

    Official Symbol
    RGPD6provided by HGNC
    Official Full Name
    RANBP2 like and GRIP domain containing 6provided by HGNC
    Primary source
    HGNC:HGNC:32419
    See related
    Ensembl:ENSG00000183054 MIM:612709; AllianceGenome:HGNC:32419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGP6; RGPD7; RanBP2L1; RanBP2L2
    Summary
    Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 24.0), brain (RPKM 8.3) and 25 other tissues See more
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    Genomic context

    Location:
    2q13
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (110513802..110611056, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (110936277..111033955, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111271379..111368633, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LIM zinc finger domain containing 4 Neighboring gene uncharacterized LOC105373552 Neighboring gene uncharacterized LOC102724875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111339275-111339775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111367745-111368317 Neighboring gene uncharacterized LOC105373553 Neighboring gene ribosomal protein L22 pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC190070

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RANBP2-like and GRIP domain-containing protein 5/6
    Names
    RANBP2-like and GRIP domain-containing protein 7
    ran-binding protein 2-like 1/2
    ranBP2-like 1/2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037866.2NP_001032955.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 2

      See identical proteins and their annotated locations for NP_001032955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC108938, AC226101
      Consensus CDS
      CCDS42729.1
      Related
      ENSP00000330023.5, ENST00000330331.9
      Conserved Domains (3) summary
      sd00006
      Location:5989
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:6092
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:59126
      TPR_11; TPR repeat
    2. NM_001123363.4NP_001116835.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 1

      See identical proteins and their annotated locations for NP_001116835.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC108938, AC226101
      Consensus CDS
      CCDS46388.1
      UniProtKB/Swiss-Prot
      Q53QN2, Q53T03, Q59GM7, Q99666, Q9H0B2
      UniProtKB/TrEMBL
      A0A8Q3SIN4, V9HWE4
      Related
      ENSP00000330842.3, ENST00000329516.8
      Conserved Domains (8) summary
      COG5171
      Location:9751167
      YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
      cd13177
      Location:10511167
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13481464
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:5989
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:6092
      TPR_1; Tetratricopeptide repeat
      pfam01465
      Location:17071749
      GRIP; GRIP domain
      pfam13414
      Location:59126
      TPR_11; TPR repeat
      pfam16704
      Location:16411705
      Rab_bind; Rab binding domain
    3. NM_001384362.1NP_001371291.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108938, AC226101
      UniProtKB/TrEMBL
      J3KQ37
      Conserved Domains (4) summary
      cd13177
      Location:766882
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:10631179
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      pfam16704
      Location:13561420
      Rab_bind; Rab binding domain
      pfam01465
      Location:14221464
      GRIP; GRIP domain
    4. NM_001384363.1NP_001371292.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108938, AC226101
      Consensus CDS
      CCDS92839.1
      UniProtKB/TrEMBL
      A0A8Q3SII4, A0A8Q3SIN4
      Related
      ENSP00000512635.1, ENST00000696448.1
      Conserved Domains (7) summary
      COG0457
      Location:13109
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13177
      Location:10341150
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13311447
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:4272
      TPR; TPR repeat [structural motif]
      pfam16704
      Location:16241688
      Rab_bind; Rab binding domain
      pfam00515
      Location:4375
      TPR_1; Tetratricopeptide repeat
      pfam01465
      Location:16901732
      GRIP; GRIP domain
    5. NM_001384364.1NP_001371293.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC108938, AC226101
      UniProtKB/TrEMBL
      A0A8Q3SIN4
      Conserved Domains (7) summary
      COG0457
      Location:4100
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13177
      Location:10251141
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13221438
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:3363
      TPR; TPR repeat [structural motif]
      pfam16704
      Location:16151679
      Rab_bind; Rab binding domain
      pfam00515
      Location:3466
      TPR_1; Tetratricopeptide repeat
      pfam01465
      Location:16811723
      GRIP; GRIP domain
    6. NM_001386141.1NP_001373070.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108938, AC226101
      UniProtKB/TrEMBL
      J3KQ37
      Conserved Domains (4) summary
      cd13177
      Location:766882
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:10631179
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      pfam16704
      Location:13561420
      Rab_bind; Rab binding domain
      pfam01465
      Location:14221464
      GRIP; GRIP domain
    7. NM_001386145.1NP_001373074.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC108938, AC226101
      UniProtKB/TrEMBL
      A0A8Q3SIN4
      Conserved Domains (7) summary
      COG0457
      Location:29125
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13177
      Location:10501166
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13471463
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:5888
      TPR; TPR repeat [structural motif]
      pfam16704
      Location:16401704
      Rab_bind; Rab binding domain
      pfam00515
      Location:5991
      TPR_1; Tetratricopeptide repeat
      pfam01465
      Location:17061748
      GRIP; GRIP domain
    8. NM_001386155.1NP_001373084.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108938, AC226101
      UniProtKB/TrEMBL
      J3KQ37
      Conserved Domains (4) summary
      cd13177
      Location:766882
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:10631179
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      pfam16704
      Location:13561420
      Rab_bind; Rab binding domain
      pfam01465
      Location:14221464
      GRIP; GRIP domain
    9. NM_001386159.1NP_001373088.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108938, AC226101
      UniProtKB/TrEMBL
      J3KQ37
      Conserved Domains (4) summary
      cd13177
      Location:766882
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:10631179
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      pfam16704
      Location:13561420
      Rab_bind; Rab binding domain
      pfam01465
      Location:14221464
      GRIP; GRIP domain
    10. NM_001386163.1NP_001373092.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC108938, AC226101
      UniProtKB/TrEMBL
      B4DTT2
      Conserved Domains (4) summary
      cd13177
      Location:396512
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:693809
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      pfam16704
      Location:9861050
      Rab_bind; Rab binding domain
      pfam01465
      Location:10521094
      GRIP; GRIP domain
    11. NM_001387273.1NP_001374202.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108938, AC226101
      UniProtKB/TrEMBL
      J3KQ37
      Conserved Domains (4) summary
      cd13177
      Location:766882
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:10631179
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      pfam16704
      Location:13561420
      Rab_bind; Rab binding domain
      pfam01465
      Location:14221464
      GRIP; GRIP domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      110513802..110611056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445731.1XP_047301687.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X2

    2. XM_047445732.1XP_047301688.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X3

    3. XM_017004839.2XP_016860328.2  RANBP2-like and GRIP domain-containing protein 5/6 isoform X1

    4. XM_047445733.1XP_047301689.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X8

    5. XM_017004841.2XP_016860330.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SIN4
    6. XM_011511770.3XP_011510072.2  RANBP2-like and GRIP domain-containing protein 5/6 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3SII5
      Related
      ENSP00000512636.1, ENST00000696449.1
    7. XM_011511769.3XP_011510071.2  RANBP2-like and GRIP domain-containing protein 5/6 isoform X5

    8. XM_017004843.2XP_016860332.2  RANBP2-like and GRIP domain-containing protein 5/6 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      110936277..111033955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343727.1XP_054199702.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X1

    2. XM_054343732.1XP_054199707.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X8

    3. XM_054343728.1XP_054199703.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X4

    4. XM_054343731.1XP_054199706.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3SII5
    5. XM_054343729.1XP_054199704.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X5

    6. XM_054343730.1XP_054199705.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_169873.1: Suppressed sequence

      Description
      NR_169873.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.