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    Ddx41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 [ Mus musculus (house mouse) ]

    Gene ID: 72935, updated on 5-Mar-2019

    Summary

    Official Symbol
    Ddx41provided by MGI
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 41provided by MGI
    Primary source
    MGI:MGI:1920185
    See related
    Ensembl:ENSMUSG00000021494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ABS; AA958953; AI324246; 2900024F02Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 33.6), spleen adult (RPKM 30.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ddx41 in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (55530410..55536658, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55631771..55638019, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 7 Neighboring gene microRNA 6945 Neighboring gene docking protein 3 Neighboring gene predicted gene, 46416 Neighboring gene family with sequence similarity 193, member B Neighboring gene predicted gene, 46417 Neighboring gene predicted gene, 31364

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-beta IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX41
    Names
    DEAD box protein 41
    DEAD-box protein abstrakt
    NP_598820.2
    XP_017171100.1
    XP_017171101.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134059.2NP_598820.2  probable ATP-dependent RNA helicase DDX41

      See identical proteins and their annotated locations for NP_598820.2

      Status: VALIDATED

      Source sequence(s)
      AK013586, AK151427, BE864921, CJ303880, CX231996
      Consensus CDS
      CCDS26549.1
      UniProtKB/Swiss-Prot
      Q91VN6
      UniProtKB/TrEMBL
      Q3UAC4, Q9CUY2
      Related
      ENSMUSP00000021956.8, ENSMUST00000021956.8
      Conserved Domains (3) summary
      smart00487
      Location:196409
      DEXDc; DEAD-like helicases superfamily
      cd00268
      Location:183397
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:418527
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      55530410..55536658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315611.1XP_017171100.1  probable ATP-dependent RNA helicase DDX41 isoform X1

    2. XM_017315612.1XP_017171101.1  probable ATP-dependent RNA helicase DDX41 isoform X2

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