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    CDK11A cyclin dependent kinase 11A [ Homo sapiens (human) ]

    Gene ID: 728642, updated on 7-Apr-2024

    Summary

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    Official Symbol
    CDK11Aprovided by HGNC
    Official Full Name
    cyclin dependent kinase 11Aprovided by HGNC
    Primary source
    HGNC:HGNC:1730
    See related
    Ensembl:ENSG00000008128 MIM:116951; AllianceGenome:HGNC:1730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110
    Summary
    This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in bone marrow (RPKM 22.4), small intestine (RPKM 18.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    1p36.33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1702379..1724357, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1136811..1158725, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1633818..1655796, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member E2B Neighboring gene ribosomal protein S7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 31 Neighboring gene Sharpr-MPRA regulatory region 10763 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1618619-1618776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1619919-1620419 Neighboring gene Sharpr-MPRA regulatory region 15043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 88 Neighboring gene matrix metallopeptidase 23A (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 32 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1655889-1656728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1660738-1661238 Neighboring gene solute carrier family 35 member E2A (pseudogene) Neighboring gene ribosomal protein S7 pseudogene Neighboring gene uncharacterized LOC112268218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 89 Neighboring gene NAD kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CDK11(p58) is required for the maintenance of sister chromatid cohesion. Hu D, et al. J Cell Sci, 2007 Jul 15. PMID 17606997
    2. Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort. Li Y, et al. Diabetes Metab Res Rev, 2007 Sep. PMID 17177267
    3. Death-signal-induced relocalization of cyclin-dependent kinase 11 to mitochondria. Feng Y, et al. Biochem J, 2005 Nov 15. PMID 16004605, Free PMC Article
    4. CDK11(p110) plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target. Du Y, et al. Cell Cycle, 2019 Feb. PMID 30722725, Free PMC Article
    5. The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. Zhou Y, et al. Oncotarget, 2016 Jun 28. PMID 27049727, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11(p110).
      Title: Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11(p110).
    2. These results provided evidence that CDK11(p110) play a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells, which suggests that CDK11(p110) may be a promising therapeutic target in esophageal squamous cell carcinoma.
      Title: CDK11(p110) plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.
    3. CDK11 has a role in human cancers [review]
      Title: The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.
    4. study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression
      Title: CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.
    5. These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells.
      Title: Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation.
    6. Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.
      Title: Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
    8. CDC2L2 gene may contribute to the susceptibility of type 2 diabetes in the northern Han Chinese population.
      Title: Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort.
    9. findings show that, in addition to playing a role in spindle formation and structure, CDK11(p58) is also required for sister chromatid cohesion and the completion of mitosis
      Title: CDK11(p58) is required for the maintenance of sister chromatid cohesion.
    10. mitotic CDK11(p58) isoform, but not the CDK11(p110) isoform, associates with mitotic centrosomes
      Title: The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ55257, FLJ56415, FLJ56557, MGC131975

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell growth IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase 11A
    Names
    PITSLRE B
    PITSLRE serine/threonine-protein kinase CDC2L2
    cell division cycle 2-like 2 (PITSLRE proteins)
    cell division cycle 2-like protein kinase 2
    cell division protein kinase 11A
    galactosyltransferase-associated protein kinase p58/GTA
    NP_001300825.1
    NP_001300911.1
    NP_076916.2
    NP_277071.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029414.1 RefSeqGene

      Range
      4996..26974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313896.2 → NP_001300825.1  cyclin-dependent kinase 11A isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the central coding region compared to variant 1. The encoded isoform (5) is longer than isoform 1.
      Source sequence(s)
      AF067522, AL031282, BC073855
      Consensus CDS
      CCDS81253.1
      UniProtKB/Swiss-Prot
      O95227, O95228, O96012, Q12821, Q12853, Q12854, Q2TAJ0, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ88, Q9UQ89
      UniProtKB/TrEMBL
      B4E3D9
      Related
      ENSP00000367900.1, ENST00000378633.5
      Conserved Domains (2) summary
      cd07843
      Location:420 → 711
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:423 → 713
      PLN00009; cyclin-dependent kinase A; Provisional

    2. NM_001313982.2 → NP_001300911.1  cyclin-dependent kinase 11A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites in 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AF067520, AL031282, BC073855
      Consensus CDS
      CCDS81254.1
      UniProtKB/TrEMBL
      B4E3D9, Q5QPR3
      Related
      ENSP00000350403.2, ENST00000357760.6
      Conserved Domains (2) summary
      cd07843
      Location:416 → 707
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:419 → 709
      PLN00009; cyclin-dependent kinase A; Provisional

    3. NM_024011.4 → NP_076916.2  cyclin-dependent kinase 11A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AF067519, AL031282, AL043340, BC073855, BC094827, DC388505
      Consensus CDS
      CCDS44042.1
      UniProtKB/TrEMBL
      B4E3D9
      Related
      ENSP00000384442.3, ENST00000404249.8
      Conserved Domains (2) summary
      cd07843
      Location:417 → 708
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:420 → 710
      PLN00009; cyclin-dependent kinase A; Provisional

    4. NM_033529.4 → NP_277071.2  cyclin-dependent kinase 11A isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF067521, AL031282, AL043340, BC073855, BC094827, DC388505
      Consensus CDS
      CCDS44043.1
      UniProtKB/TrEMBL
      B4E3D9
      Related
      ENSP00000351629.5, ENST00000358779.9
      Conserved Domains (2) summary
      cd07843
      Location:407 → 698
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:410 → 700
      PLN00009; cyclin-dependent kinase A; Provisional

    RNA

    1. NR_132739.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF067518, AL031282, BC073855
      Related
      ENST00000460465.5

    2. NR_132740.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses two alternate internal splice sites compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF067523, AL031282, BC073855

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1702379..1724357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1136811..1158725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033527.1: Suppressed sequence

      Description
      NM_033527.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_033532.1: Suppressed sequence

      Description
      NM_033532.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    3. NM_033534.1: Suppressed sequence

      Description
      NM_033534.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UQ88.4 GenPept UniProtKB/Swiss-Prot:Q9UQ88

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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