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    METTL24 methyltransferase like 24 [ Homo sapiens (human) ]

    Gene ID: 728464, updated on 17-Jun-2024

    Summary

    Official Symbol
    METTL24provided by HGNC
    Official Full Name
    methyltransferase like 24provided by HGNC
    Primary source
    HGNC:HGNC:21566
    See related
    Ensembl:ENSG00000053328 AllianceGenome:HGNC:21566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C6orf186
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in endometrium (RPKM 3.7), gall bladder (RPKM 2.6) and 20 other tissues See more
    Orthologs
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    Genomic context

    See METTL24 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (110243940..110358349, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (111422396..111536825, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110565143..110679552, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110437149-110437694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110437695-110438238 Neighboring gene WASP family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17466 Neighboring gene cell division cycle 40 Neighboring gene uncharacterized LOC105377937 Neighboring gene MPRA-validated peak6023 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:110591233-110591734 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110644043-110644650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:110651303-110651803 Neighboring gene uncharacterized LOC102724586 Neighboring gene Sharpr-MPRA regulatory region 3191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:110729777-110730278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:110730279-110730778 Neighboring gene uncharacterized LOC105377936 Neighboring gene D-aspartate oxidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included genes: DDO, WASF1

    Clone Names

    • FLJ45203

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable methyltransferase-like protein 24
    Names
    UPF0624 protein C6orf186
    methyltransferase-like protein 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123364.3NP_001116836.1  probable methyltransferase-like protein 24 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001116836.1

      Status: VALIDATED

      Source sequence(s)
      AL050350, AL445068
      Consensus CDS
      CCDS43489.1
      UniProtKB/Swiss-Prot
      Q5JXM2, Q6ZSU5
      Related
      ENSP00000344071.4, ENST00000338882.5
      Conserved Domains (1) summary
      cl17173
      Location:248298
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001354594.2NP_001341523.1  probable methyltransferase-like protein 24 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL050350, AL445068
      Conserved Domains (1) summary
      cl17173
      Location:51101
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_001354595.2NP_001341524.1  probable methyltransferase-like protein 24 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL050350, AL445068
      Conserved Domains (1) summary
      cl17173
      Location:51101
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      110243940..110358349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      111422396..111536825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)