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    TSPY3 testis specific protein Y-linked 3 [ Homo sapiens (human) ]

    Gene ID: 728137, updated on 3-Apr-2024

    Summary

    Official Symbol
    TSPY3provided by HGNC
    Official Full Name
    testis specific protein Y-linked 3provided by HGNC
    Primary source
    HGNC:HGNC:33876
    See related
    Ensembl:ENSG00000228927 AllianceGenome:HGNC:33876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT78; TSPY; TSPY1; TSPY10
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in sex differentiation. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 34.5) See more
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    Genomic context

    See TSPY3 in Genome Data Viewer
    Location:
    Yp11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (9398421..9401217)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (9187133..9189929)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9236030..9238826)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis specific protein Y-linked 7, pseudogene Neighboring gene family with sequence similarity 197 Y-linked member 6 Neighboring gene family with sequence similarity 197 Y-linked member 5 Neighboring gene testis specific protein Y-linked 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gonadal mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    testis-specific Y-encoded protein 3
    Names
    Cancer/testis antigen 78
    Testis-specific Y-encoded protein 1
    Testis-specific Y-encoded protein 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077697.2NP_001071165.2  testis-specific Y-encoded protein 3

      See identical proteins and their annotated locations for NP_001071165.2

      Status: VALIDATED

      Source sequence(s)
      AC006158
      Consensus CDS
      CCDS48204.1
      UniProtKB/Swiss-Prot
      P0CV98, P0CW01
      UniProtKB/TrEMBL
      Q540R4
      Related
      ENSP00000398163.2, ENST00000457222.6
      Conserved Domains (1) summary
      cl08298
      Location:126288
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      9398421..9401217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272742.5XP_005272799.1  testis-specific Y-encoded protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005272799.1

      UniProtKB/TrEMBL
      F2Z2I4, Q540R4
      Related
      ENSP00000412988.1, ENST00000424594.1
      Conserved Domains (1) summary
      cl08298
      Location:103273
      NAP; Nucleosome assembly protein (NAP)
    2. XM_011544004.3XP_011542306.1  testis-specific Y-encoded protein 3 isoform X2

      Conserved Domains (1) summary
      cl08298
      Location:112223
      NAP; Nucleosome assembly protein (NAP)

    RNA

    1. XR_949063.3 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791821.1 Reference GRCh38.p14 PATCHES

      Range
      265650..268446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333418.1XP_054189393.1  testis-specific Y-encoded protein 3 isoform X1

      UniProtKB/TrEMBL
      F2Z2I4
    2. XM_054333419.1XP_054189394.1  testis-specific Y-encoded protein 3 isoform X2

    RNA

    1. XR_008485839.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      9187133..9189929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328327.1XP_054184302.1  testis-specific Y-encoded protein 3 isoform X1

      UniProtKB/TrEMBL
      F2Z2I4
    2. XM_054328328.1XP_054184303.1  testis-specific Y-encoded protein 3 isoform X2

    RNA

    1. XR_008485525.1 RNA Sequence