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    ZBTB8B zinc finger and BTB domain containing 8B [ Homo sapiens (human) ]

    Gene ID: 728116, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZBTB8Bprovided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 8Bprovided by HGNC
    Primary source
    HGNC:HGNC:37057
    See related
    Ensembl:ENSG00000273274 AllianceGenome:HGNC:37057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF916B
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See ZBTB8B in Genome Data Viewer
    Location:
    1p35.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32465072..32496686)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32322988..32354613)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32930673..32962287)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A12, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 691 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:32903713-32904496 Neighboring gene RNA, 7SL, cytoplasmic 122, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 601 Neighboring gene uncharacterized LOC124903952 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:33013203-33013387 Neighboring gene MPRA-validated peak165 silencer Neighboring gene zinc finger and BTB domain containing 8A Neighboring gene MPRA-validated peak166 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33072181-33072681 Neighboring gene uncharacterized LOC102723870 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33077607-33078108

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ZBTB8A

    Clone Names

    • DKFZp547H154

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 8B
    Names
    putative zinc finger and BTB domain-containing protein 8B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145720.2NP_001139192.1  zinc finger and BTB domain-containing protein 8B

      See identical proteins and their annotated locations for NP_001139192.1

      Status: VALIDATED

      Source sequence(s)
      AL033529, AL356986
      Consensus CDS
      CCDS44104.1
      UniProtKB/Swiss-Prot
      Q15DG5, Q5VXR5, Q69YT7, Q8NAP8
      Related
      ENSP00000476499.1, ENST00000609129.2
      Conserved Domains (4) summary
      sd00017
      Location:343363
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18330
      Location:6118
      BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
      pfam13909
      Location:341365
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam13465
      Location:356380
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      32465072..32496686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32322988..32354613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)