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    Sass6 SAS-6 centriolar assembly protein [ Mus musculus (house mouse) ]

    Gene ID: 72776, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sass6provided by MGI
    Official Full Name
    SAS-6 centriolar assembly proteinprovided by MGI
    Primary source
    MGI:MGI:1920026
    See related
    Ensembl:ENSMUSG00000027959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810453L12Rik
    Expression
    Broad expression in testis adult (RPKM 4.7), CNS E11.5 (RPKM 4.0) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sass6 in Genome Data Viewer
    Location:
    3; 3 G1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116388577..116424816)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116594938..116630986)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (116297926..116333902)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene splicing factor, arginine/serine-rich pseudogene Neighboring gene leucine rich repeat containing 39 Neighboring gene tRNA methyltransferase 13 Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene microRNA 3473h Neighboring gene solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3 Neighboring gene predicted gene, 40126

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in deuterosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    spindle assembly abnormal protein 6 homolog
    Names
    spindle assembly 6 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289568.1NP_001276497.1  spindle assembly abnormal protein 6 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon, that causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC131038, AK013338, AK165224, BB617231, BQ174648
      UniProtKB/Swiss-Prot
      Q80UK7
      Conserved Domains (2) summary
      cd00187
      Location:266386
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      pfam16531
      Location:646
      SAS-6_N; Centriolar protein SAS N-terminal
    2. NM_001289571.1NP_001276500.1  spindle assembly abnormal protein 6 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, that causes translation initiation at a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC131038, AK013338, AK165224, BB617231, BQ174648
      Consensus CDS
      CCDS80008.1
      UniProtKB/Swiss-Prot
      Q80UK7
      UniProtKB/TrEMBL
      A0A0G2JFC9
      Related
      ENSMUSP00000143123.2, ENSMUST00000197335.2
      Conserved Domains (3) summary
      cd00187
      Location:325445
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      pfam16531
      Location:11105
      SAS-6_N; Centriolar protein SAS N-terminal
      cl21455
      Location:21313
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_028349.3NP_082625.2  spindle assembly abnormal protein 6 homolog isoform 1

      See identical proteins and their annotated locations for NP_082625.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC131038, AK013338, AK165224, BB617231, BQ174648
      Consensus CDS
      CCDS17789.1
      UniProtKB/Swiss-Prot
      Q80UK7
      Related
      ENSMUSP00000143233.2, ENSMUST00000198311.5
      Conserved Domains (3) summary
      cd00187
      Location:360480
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      pfam16531
      Location:46140
      SAS-6_N; Centriolar protein SAS N-terminal
      cl21455
      Location:56348
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      116388577..116424816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502140.5XP_006502203.1  spindle assembly abnormal protein 6 homolog isoform X1

      Conserved Domains (3) summary
      TIGR02168
      Location:167483
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16531
      Location:46141
      SAS-6_N; Centriolar protein SAS N-terminal
      pfam18594
      Location:146171
      Sas6_CC; Sas6/XLF/XRCC4 coiled-coil domain
    2. XM_006502141.5XP_006502204.1  spindle assembly abnormal protein 6 homolog isoform X2

      Conserved Domains (3) summary
      TIGR02168
      Location:167483
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16531
      Location:46141
      SAS-6_N; Centriolar protein SAS N-terminal
      pfam18594
      Location:146171
      Sas6_CC; Sas6/XLF/XRCC4 coiled-coil domain
    3. XM_036163351.1XP_036019244.1  spindle assembly abnormal protein 6 homolog isoform X3

      Related
      ENSMUSP00000143175.2, ENSMUST00000198386.5
      Conserved Domains (3) summary
      TIGR02168
      Location:165450
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18594
      Location:146171
      Sas6_CC; Sas6/XLF/XRCC4 coiled-coil domain
      cd10142
      Location:4144
      HD_SAS6_N; N-terminal head domain found in spindle assembly abnormal protein 6 and similar proteins
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