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    Cdc42se2 CDC42 small effector 2 [ Mus musculus (house mouse) ]

    Gene ID: 72729, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cdc42se2provided by MGI
    Official Full Name
    CDC42 small effector 2provided by MGI
    Primary source
    MGI:MGI:1919979
    See related
    Ensembl:ENSMUSG00000052298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPE; SPEC2; AA408783; AA536669; 2810404F18Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 40.6), large intestine adult (RPKM 40.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cdc42se2 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54608241..54678549, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54717415..54787703, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54530917..54601205, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115487771 Neighboring gene folliculin interacting protein 1 Neighboring gene predicted gene, 24198 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 6 Neighboring gene predicted gene 12227 Neighboring gene LYR motif containing 7, opposite strand Neighboring gene LYR motif containing 7 Neighboring gene ATPase family, AAA domain containing 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CDC42 small effector protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178626.3NP_848741.1  CDC42 small effector protein 2

      See identical proteins and their annotated locations for NP_848741.1

      Status: VALIDATED

      Source sequence(s)
      AK135775, AK160934, BY688282, CJ072588
      Consensus CDS
      CCDS36153.1
      UniProtKB/Swiss-Prot
      Q8BGH7
      Related
      ENSMUSP00000070725.7, ENSMUST00000064104.13
      Conserved Domains (1) summary
      cd00132
      Location:2767
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54608241..54678549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534320.4XP_006534383.1  CDC42 small effector protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006534383.1

      UniProtKB/Swiss-Prot
      Q8BGH7
      Conserved Domains (1) summary
      cd00132
      Location:2767
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    2. XM_030246369.2XP_030102229.1  CDC42 small effector protein 2 isoform X1

      Conserved Domains (1) summary
      cd00132
      Location:2767
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    3. XM_030246370.1XP_030102230.1  CDC42 small effector protein 2 isoform X1

      Conserved Domains (1) summary
      cd00132
      Location:2767
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
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