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    Cdc42se2 CDC42 small effector 2 [ Mus musculus (house mouse) ]

    Gene ID: 72729, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdc42se2provided by MGI
    Official Full Name
    CDC42 small effector 2provided by MGI
    Primary source
    MGI:MGI:1919979
    See related
    Ensembl:ENSMUSG00000052298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPEC2; AA408783; AA536669; 2810404F18Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 40.6), large intestine adult (RPKM 40.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdc42se2 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (54717415..54787703, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54530917..54601205, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene folliculin interacting protein 1 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 6 Neighboring gene LYR motif containing 7, opposite strand Neighboring gene LYR motif containing 7 Neighboring gene ATPase family, AAA domain containing 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rho GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CDC42 small effector protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178626.3NP_848741.1  CDC42 small effector protein 2

      See identical proteins and their annotated locations for NP_848741.1

      Status: VALIDATED

      Source sequence(s)
      AK135775, AK160934, BY688282, CJ072588
      Consensus CDS
      CCDS36153.1
      UniProtKB/Swiss-Prot
      Q8BGH7
      Related
      ENSMUSP00000070725.6, ENSMUST00000064104.12
      Conserved Domains (1) summary
      cd00132
      Location:2767
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      54717415..54787703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534320.2XP_006534383.1  CDC42 small effector protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006534383.1

      UniProtKB/Swiss-Prot
      Q8BGH7
      Conserved Domains (1) summary
      cd00132
      Location:2767
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
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