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    Ppme1 protein phosphatase methylesterase 1 [ Mus musculus (house mouse) ]

    Gene ID: 72590, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ppme1provided by MGI
    Official Full Name
    protein phosphatase methylesterase 1provided by MGI
    Primary source
    MGI:MGI:1919840
    See related
    Ensembl:ENSMUSG00000030718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PME-; Pme1; PME-1; 1110069N17Rik; 2700017M01Rik
    Expression
    Ubiquitous expression in cortex adult (RPKM 60.3), frontal lobe adult (RPKM 53.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ppme1 in Genome Data Viewer
    Location:
    7; 7 E2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99975944..100021103, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100326737..100371896, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (107475247..107520406, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 2-like 1 Neighboring gene glutathione peroxidase 2, pseudogene 1 Neighboring gene procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III Neighboring gene C2 calcium-dependent domain containing 3 Neighboring gene predicted gene 10603 Neighboring gene uncoupling protein 3 (mitochondrial, proton carrier)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminal methylesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein methylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein demethylation ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein phosphatase methylesterase 1
    NP_082568.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028292.2NP_082568.1  protein phosphatase methylesterase 1

      See identical proteins and their annotated locations for NP_082568.1

      Status: PROVISIONAL

      Source sequence(s)
      AC122269
      Consensus CDS
      CCDS40036.1
      UniProtKB/Swiss-Prot
      Q8BVQ5
      Related
      ENSMUSP00000032963.9, ENSMUST00000032963.10
      Conserved Domains (3) summary
      COG0596
      Location:66370
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:78195
      Abhydrolase_5; Alpha/beta hydrolase family
      cl17036
      Location:270306
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      99975944..100021103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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