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    TSPYL1 TSPY like 1 [ Homo sapiens (human) ]

    Gene ID: 7259, updated on 17-Jun-2024

    Summary

    Official Symbol
    TSPYL1provided by HGNC
    Official Full Name
    TSPY like 1provided by HGNC
    Primary source
    HGNC:HGNC:12382
    See related
    Ensembl:ENSG00000189241 MIM:604714; AllianceGenome:HGNC:12382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSPYL
    Summary
    The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TSPYL1 in Genome Data Viewer
    Location:
    6q22.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (116274858..116279930, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (117458843..117463912, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116596021..116601093, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24982 Neighboring gene ribosomal protein S5 pseudogene Neighboring gene TSPY like 4 Neighboring gene NANOG hESC enhancer GRCh37_chr6:116592289-116592790 Neighboring gene RPS5 pseudogene 1 Neighboring gene dermatan sulfate epimerase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24985 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88171 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:116644935-116645502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:116646525-116647026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24986 Neighboring gene uncharacterized LOC100287467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24987 Neighboring gene Sharpr-MPRA regulatory region 2122 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:116692481-116692981 Neighboring gene Sharpr-MPRA regulatory region 1381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:116720114-116720614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:116720615-116721115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17494 Neighboring gene CBX3 pseudogene 9

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr interacts with TSPYL1 and C20orf94 subunits of the SLX4 complex in Vpr-expressing THP-1 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    testis-specific Y-encoded-like protein 1
    Names
    TSPY-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016217.1 RefSeqGene

      Range
      5001..10259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_862

    mRNA and Protein(s)

    1. NM_003309.4NP_003300.1  testis-specific Y-encoded-like protein 1

      See identical proteins and their annotated locations for NP_003300.1

      Status: REVIEWED

      Source sequence(s)
      AL050331
      Consensus CDS
      CCDS34518.1
      UniProtKB/Swiss-Prot
      O75885, Q5TFE6, Q9H0U9
      UniProtKB/TrEMBL
      Q6FI91
      Related
      ENSP00000357597.4, ENST00000368608.4
      Conserved Domains (1) summary
      pfam00956
      Location:228409
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      116274858..116279930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      117458843..117463912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)