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    Cul4b cullin 4B [ Mus musculus (house mouse) ]

    Gene ID: 72584, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cul4bprovided by MGI
    Official Full Name
    cullin 4Bprovided by MGI
    Primary source
    MGI:MGI:1919834
    See related
    Ensembl:ENSMUSG00000031095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CUL-4B; AA409770; mKIAA0695; 2700050M05Rik
    Expression
    Broad expression in placenta adult (RPKM 24.3), CNS E11.5 (RPKM 9.0) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Cul4b in Genome Data Viewer
    Location:
    X; X A3.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (37620493..37665073, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (38531616..38576196, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (35884793..35929373, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 94 pseudogene Neighboring gene predicted gene 9488 Neighboring gene malignant T cell amplified sequence 1 Neighboring gene C1GALT1-specific chaperone 1 Neighboring gene predicted gene, 52440 Neighboring gene MAK16 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0695

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in UV-damage excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H2A monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4B-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cul4B-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110142.1NP_001103612.1  cullin-4B

      See identical proteins and their annotated locations for NP_001103612.1

      Status: VALIDATED

      Source sequence(s)
      AI037712, AK032701, AK160998, AK164640, CJ072585
      Consensus CDS
      CCDS40948.1
      UniProtKB/Swiss-Prot
      A2A432
      UniProtKB/TrEMBL
      Q3TP81
      Related
      ENSMUSP00000059276.6, ENSMUST00000050083.6
      Conserved Domains (3) summary
      smart00182
      Location:653793
      CULLIN; Cullin
      smart00884
      Location:899964
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:275870
      Cullin; Cullin family
    2. NM_028288.5NP_082564.3  cullin-4B

      See identical proteins and their annotated locations for NP_082564.3

      Status: VALIDATED

      Source sequence(s)
      AI037712, AK032701, AK160998, AK164640
      Consensus CDS
      CCDS40948.1
      UniProtKB/Swiss-Prot
      A2A432
      UniProtKB/TrEMBL
      Q3TP81
      Related
      ENSMUSP00000110771.2, ENSMUST00000115118.8
      Conserved Domains (3) summary
      smart00182
      Location:653793
      CULLIN; Cullin
      smart00884
      Location:899964
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:275870
      Cullin; Cullin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      37620493..37665073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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