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    Bclaf1 BCL2-associated transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 72567, updated on 31-Jan-2019

    Summary

    Official Symbol
    Bclaf1provided by MGI
    Official Full Name
    BCL2-associated transcription factor 1provided by MGI
    Primary source
    MGI:MGI:1917580
    See related
    Ensembl:ENSMUSG00000037608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Btf; AI450190; AW556225; mKIAA0164; 2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.7), CNS E14 (RPKM 17.4) and 24 other tissues See more
    Orthologs

    Genomic context

    See Bclaf1 in Genome Data Viewer
    Location:
    10; 10 A3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (20312078..20342644)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (20032275..20062307)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30285 Neighboring gene microRNA 6413 Neighboring gene mitochondrial fission regulator 2 Neighboring gene phosphodiesterase 7B Neighboring gene F-box protein 34 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0164, MGC30519, MGC58035

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bcl-2-associated transcription factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025392.1NP_001020563.1  bcl-2-associated transcription factor 1 isoform 1

      See identical proteins and their annotated locations for NP_001020563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC029682, BC034300, BY071148, CAAA01031508
      Consensus CDS
      CCDS35858.1
      UniProtKB/Swiss-Prot
      Q8K019
      Related
      ENSMUSP00000043583.5, ENSMUST00000043881.11
      Conserved Domains (2) summary
      pfam15440
      Location:157744
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      cl09653
      Location:826891
      Btz; CASC3/Barentsz eIF4AIII binding
    2. NM_001025393.1NP_001020564.1  bcl-2-associated transcription factor 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, as compared to variant 1. The encoded isoform 3 lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      BC086624, BY071148, CAAA01031508, CK637794, CN530237
      Consensus CDS
      CCDS23721.1
      UniProtKB/TrEMBL
      F8WI22
      Related
      ENSMUSP00000090349.3, ENSMUST00000092678.9
      Conserved Domains (1) summary
      pfam15440
      Location:157744
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    3. NM_153787.2NP_722482.1  bcl-2-associated transcription factor 1 isoform 2

      See identical proteins and their annotated locations for NP_722482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 6-nt segment in the CDS, as compared to variant 1. The encoded isoform 2 lacks 2 internal aa, as compared to isoform 1.
      Source sequence(s)
      BC034300, BY071148, CAAA01031508
      Consensus CDS
      CCDS78798.1
      UniProtKB/Swiss-Prot
      Q8K019
      Related
      ENSMUSP00000140623.1, ENSMUST00000185800.6
      Conserved Domains (2) summary
      pfam15440
      Location:155742
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      cl09653
      Location:824889
      Btz; CASC3/Barentsz eIF4AIII binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      20312078..20342644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512865.3XP_006512928.1  bcl-2-associated transcription factor 1 isoform X1

      Conserved Domains (1) summary
      pfam15440
      Location:155742
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    2. XM_011243207.2XP_011241509.1  bcl-2-associated transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A087WQA0
      Related
      ENSMUSP00000140101.1, ENSMUST00000186100.6
      Conserved Domains (1) summary
      pfam15440
      Location:157739
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    3. XM_006512866.3XP_006512929.1  bcl-2-associated transcription factor 1 isoform X3

      Conserved Domains (1) summary
      cl09653
      Location:217282
      Btz; CASC3/Barentsz eIF4AIII binding

    RNA

    1. XR_001779610.1 RNA Sequence

    2. XR_001779609.1 RNA Sequence

    3. XR_380077.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025394.1: Suppressed sequence

      Description
      NM_001025394.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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