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    Naalad2 N-acetylated alpha-linked acidic dipeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 72560, updated on 27-Jan-2018

    Summary

    Official Symbol
    Naalad2provided by MGI
    Official Full Name
    N-acetylated alpha-linked acidic dipeptidase 2provided by MGI
    Primary source
    MGI:MGI:1919810
    See related
    Ensembl:ENSMUSG00000043943 Vega:OTTMUSG00000036485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCP3; Folh1b; GCPIII; D9Ertd285e; NAADALASE2; NAALADASE2; 2700022G20Rik
    Expression
    Broad expression in bladder adult (RPKM 3.8), testis adult (RPKM 1.8) and 17 other tissues See more
    Orthologs

    Genomic context

    See Naalad2 in Genome Data Viewer
    Location:
    9 A2; 9 7.02 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (18321954..18397354, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (18127465..18190372, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene 7692 Neighboring gene cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 1 pseudogene Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC124348, MGC124349

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    N-formylglutamate deformylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    N-acetylated-alpha-linked acidic dipeptidase 2
    Names
    N-acetylaspartylglutamate peptidase II
    N-acetylated-alpha-linked acidic dipeptidase II
    NAAG-peptidase II
    NAALADase II
    glutamate carboxypeptidase III
    NP_082555.2
    XP_006510685.1
    XP_017169097.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357399.1NP_001344328.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC154699, AC162941, AK161457
      Conserved Domains (4) summary
      cd08022
      Location:376623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:148374
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:660771
      TFR_dimer; Transferrin receptor-like dimerisation domain
      cl14876
      Location:86142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    2. NM_001357400.1NP_001344329.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC154699, AC162941, AK135653
      Conserved Domains (4) summary
      cd08022
      Location:376623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:148374
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:660771
      TFR_dimer; Transferrin receptor-like dimerisation domain
      cl14876
      Location:86142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    3. NM_028279.4NP_082555.2  N-acetylated-alpha-linked acidic dipeptidase 2 isoform b

      See identical proteins and their annotated locations for NP_082555.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC154699, AK133611
      Consensus CDS
      CCDS52728.1
      UniProtKB/Swiss-Prot
      Q9CZR2
      UniProtKB/TrEMBL
      Q3UZV6
      Related
      ENSMUSP00000128674.1, OTTMUSP00000051891, ENSMUST00000166825.7
      Conserved Domains (4) summary
      cd08022
      Location:338585
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:110336
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:622736
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:48104
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      18321954..18397354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510622.2XP_006510685.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      Conserved Domains (4) summary
      cd08022
      Location:444691
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:216442
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:728842
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:154210
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    2. XM_017313608.1XP_017169097.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

      UniProtKB/TrEMBL
      G3UWC2
      Related
      ENSMUSP00000001826.8, OTTMUSP00000051892, ENSMUST00000001826.14, OTTMUST00000093517
      Conserved Domains (4) summary
      cd08022
      Location:376623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:148374
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:660771
      TFR_dimer; Transferrin receptor-like dimerisation domain
      cl14876
      Location:86142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
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