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    Exosc6 exosome component 6 [ Mus musculus (house mouse) ]

    Gene ID: 72544, updated on 23-Jun-2021

    Summary

    Official Symbol
    Exosc6provided by MGI
    Official Full Name
    exosome component 6provided by MGI
    Primary source
    MGI:MGI:1919794
    See related
    Ensembl:ENSMUSG00000109941
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtr; Mtr3; C76919; 2610510N21Rik
    Orthologs
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    Genomic context

    See Exosc6 in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111782971..111784296)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111056339..111057664)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (113580239..113581499)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 19a Neighboring gene predicted gene, 51551 Neighboring gene DEAD box helicase 19b Neighboring gene microRNA 3473d Neighboring gene alanyl-tRNA synthetase Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC) Neighboring gene C-type lectin domain family 18, member A

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC151362

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA deamination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in isotype switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in polyadenylation-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of isotype switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    exosome complex component MTR3
    Names
    Mtr3 (mRNA transport regulator 3)-homolog
    exosome complex exonuclease MTR3
    NP_082550.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028274.4NP_082550.1  exosome complex component MTR3

      See identical proteins and their annotated locations for NP_082550.1

      Status: VALIDATED

      Source sequence(s)
      BC116985, BM941848
      Consensus CDS
      CCDS85611.1
      UniProtKB/Swiss-Prot
      Q8BTW3
      Related
      ENSMUSP00000147696.2, ENSMUST00000210390.2
      Conserved Domains (2) summary
      cd11371
      Location:36261
      RNase_PH_MTR3; MTR3 subunit of eukaryotic exosome
      COG0689
      Location:28260
      Rph; Ribonuclease PH [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111782971..111784296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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