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    Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 72508, updated on 14-Sep-2021

    Summary

    Official Symbol
    Rps6kb1provided by MGI
    Official Full Name
    ribosomal protein S6 kinase, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1270849
    See related
    Ensembl:ENSMUSG00000020516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S6K; S6K1; p70s; p70S6; p70s6k; P70S6K1; p70/85s; AA959758; AI256796; AI314060; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.0), limb E14.5 (RPKM 4.8) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rps6kb1 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86389695..86435711, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86498869..86544885, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (86312511..86358309, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 pseudogene Neighboring gene predicted gene, 26439 Neighboring gene ring finger protein, transmembrane 1 Neighboring gene tubulin, delta 1 Neighboring gene microRNA 21a Neighboring gene vacuole membrane protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 4732464A07Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within behavioral fear response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interferon-gamma IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within germ cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of skeletal muscle tissue growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein kinase B signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase beta-1
    Names
    70 kDa ribosomal protein S6 kinase 1
    p70 S6 kinase alpha
    p70 ribosomal S6 kinase alpha
    ribosomal protein S6 kinase I
    ribosomal protein S6 kinase, 70kD, polypeptide 1
    NP_001107806.1
    NP_001350091.1
    NP_082535.1
    XP_006534378.1
    XP_011247577.1
    XP_011247578.1
    XP_036012907.1
    XP_036012908.1
    XP_036012909.1
    XP_036012910.1
    XP_036012911.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114334.2NP_001107806.1  ribosomal protein S6 kinase beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001107806.1

      Status: VALIDATED

      Source sequence(s)
      AK032724, AK135716, AL604063
      Consensus CDS
      CCDS48875.1
      UniProtKB/Swiss-Prot
      Q8BSK8
      UniProtKB/TrEMBL
      Q3UXD8
      Related
      ENSMUSP00000119715.2, ENSMUST00000154617.8
      Conserved Domains (1) summary
      cd05584
      Location:94416
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    2. NM_001363162.1NP_001350091.1  ribosomal protein S6 kinase beta-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL604063
      Conserved Domains (1) summary
      cd05584
      Location:41363
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    3. NM_028259.4NP_082535.1  ribosomal protein S6 kinase beta-1 isoform 2

      See identical proteins and their annotated locations for NP_082535.1

      Status: VALIDATED

      Source sequence(s)
      AL604063
      Consensus CDS
      CCDS25201.1
      UniProtKB/TrEMBL
      Q8C3J7
      Related
      ENSMUSP00000053188.3, ENSMUST00000058286.9
      Conserved Domains (1) summary
      cl21453
      Location:94195
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      86389695..86435711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157018.1XP_036012911.1  ribosomal protein S6 kinase beta-1 isoform X5

      Conserved Domains (1) summary
      cl21453
      Location:1157
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036157014.1XP_036012907.1  ribosomal protein S6 kinase beta-1 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    3. XM_036157016.1XP_036012909.1  ribosomal protein S6 kinase beta-1 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    4. XM_036157017.1XP_036012910.1  ribosomal protein S6 kinase beta-1 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    5. XM_036157015.1XP_036012908.1  ribosomal protein S6 kinase beta-1 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1213
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011249275.4XP_011247577.1  ribosomal protein S6 kinase beta-1 isoform X1

      Conserved Domains (1) summary
      cd05584
      Location:94416
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    7. XM_006534315.5XP_006534378.1  ribosomal protein S6 kinase beta-1 isoform X2

      Conserved Domains (1) summary
      cd05584
      Location:48336
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    8. XM_011249276.4XP_011247578.1  ribosomal protein S6 kinase beta-1 isoform X3

      Conserved Domains (1) summary
      cd05584
      Location:94409
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

    RNA

    1. XR_004937046.1 RNA Sequence

    2. XR_004937048.1 RNA Sequence

    3. XR_004937047.1 RNA Sequence

    4. XR_001780060.3 RNA Sequence

    5. XR_003949511.2 RNA Sequence

    6. XR_003949513.1 RNA Sequence

    7. XR_879743.4 RNA Sequence

    8. XR_004937043.1 RNA Sequence

    9. XR_004937042.1 RNA Sequence

    10. XR_004937044.1 RNA Sequence

    11. XR_004937045.1 RNA Sequence

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