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    Brap BRCA1 associated protein [ Mus musculus (house mouse) ]

    Gene ID: 72399, updated on 19-Feb-2019

    Summary

    Official Symbol
    Brapprovided by MGI
    Official Full Name
    BRCA1 associated proteinprovided by MGI
    Primary source
    MGI:MGI:1919649
    See related
    Ensembl:ENSMUSG00000029458
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IMP; BRAP2; 3010002G07Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 46.8), liver adult (RPKM 15.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brap in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (121660563..121687249)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122110595..122137257)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 10 Neighboring gene ataxin 2 Neighboring gene microRNA 7031 Neighboring gene SH2B adaptor protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    BRCA1-associated protein
    Names
    RING-type E3 ubiquitin transferase BRAP2
    brap
    impedes mitogenic signal propagation
    NP_001276472.1
    NP_001276473.1
    NP_082503.2
    XP_006530532.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289543.1NP_001276472.1  BRCA1-associated protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC116104, AK143718, BC062932, BY739796
      Conserved Domains (3) summary
      cd00162
      Location:114155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12718
      Location:1194
      RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
      pfam02148
      Location:168230
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. NM_001289544.1NP_001276473.1  BRCA1-associated protein isoform 3

      See identical proteins and their annotated locations for NP_001276473.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC116104
      Consensus CDS
      CCDS80389.1
      UniProtKB/Swiss-Prot
      Q99MP8
      Related
      ENSMUSP00000107395.1, ENSMUST00000111765.7
      Conserved Domains (3) summary
      cd00162
      Location:232273
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12718
      Location:129212
      RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
      pfam02148
      Location:286348
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    3. NM_028227.3NP_082503.2  BRCA1-associated protein isoform 1

      See identical proteins and their annotated locations for NP_082503.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC116104, BC062932, BY739796
      Consensus CDS
      CCDS19640.1
      UniProtKB/Swiss-Prot
      Q99MP8
      Related
      ENSMUSP00000031414.8, ENSMUST00000031414.14
      Conserved Domains (3) summary
      cd00162
      Location:262303
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12718
      Location:159242
      RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
      pfam02148
      Location:316378
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      121660563..121687249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530469.1XP_006530532.1  BRCA1-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006530532.1

      UniProtKB/Swiss-Prot
      Q99MP8
      Conserved Domains (3) summary
      cd00162
      Location:122163
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12718
      Location:19102
      RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
      pfam02148
      Location:176238
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
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