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    Brf1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit [ Mus musculus (house mouse) ]

    Gene ID: 72308, updated on 31-Jan-2019

    Summary

    Official Symbol
    Brf1provided by MGI
    Official Full Name
    BRF1, RNA polymerase III transcription initiation factor 90 kDa subunitprovided by MGI
    Primary source
    MGI:MGI:1919558
    See related
    Ensembl:ENSMUSG00000011158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GTF3B; TAF3C; TAFIII90; TFIIIB90; mTFIIIB90; 2510002F24Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 20.5), ovary adult (RPKM 14.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brf1 in Genome Data Viewer
    Location:
    12; 12 F1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (112955631..113000699, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (114198073..114238832, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 14 Neighboring gene predicted gene, 26583 Neighboring gene BTB (POZ) domain containing 6 Neighboring gene uncharacterized LOC108168035 Neighboring gene phosphofurin acidic cluster sorting protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase III general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase III type 3 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA-templated transcription, initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase III preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
     
    transcription preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor TFIIIB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor IIIB 90 kDa subunit
    Names
    B-related factor 1
    BRF-1
    BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB
    hTFIIIB90

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028193.3NP_082469.2  transcription factor IIIB 90 kDa subunit

      See identical proteins and their annotated locations for NP_082469.2

      Status: VALIDATED

      Source sequence(s)
      AC073562, AC160929
      Consensus CDS
      CCDS49195.1
      UniProtKB/TrEMBL
      G3X8S2
      Related
      ENSMUSP00000011302.7, ENSMUST00000011302.8
      Conserved Domains (5) summary
      COG1405
      Location:4266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:93170
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam07741
      Location:453545
      BRF1; Brf1-like TBP-binding domain
      pfam08271
      Location:443
      TF_Zn_Ribbon; TFIIB zinc-binding
      cl00050
      Location:187260
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      112955631..113000699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516260.3XP_006516323.1  transcription factor IIIB 90 kDa subunit isoform X1

      See identical proteins and their annotated locations for XP_006516323.1

      UniProtKB/TrEMBL
      G3X8S2
      Conserved Domains (5) summary
      COG1405
      Location:4266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:93170
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam07741
      Location:453545
      BRF1; Brf1-like TBP-binding domain
      pfam08271
      Location:443
      TF_Zn_Ribbon; TFIIB zinc-binding
      cl00050
      Location:187260
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    2. XM_006516261.3XP_006516324.1  transcription factor IIIB 90 kDa subunit isoform X2

      Conserved Domains (5) summary
      COG1405
      Location:4266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:93170
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam07741
      Location:452544
      BRF1; Brf1-like TBP-binding domain
      pfam08271
      Location:443
      TF_Zn_Ribbon; TFIIB zinc-binding
      cl00050
      Location:187260
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    3. XM_011244182.2XP_011242484.1  transcription factor IIIB 90 kDa subunit isoform X3

      See identical proteins and their annotated locations for XP_011242484.1

      Conserved Domains (3) summary
      COG1405
      Location:24132
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:319411
      BRF1; Brf1-like TBP-binding domain
      cl00050
      Location:53126
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    4. XM_017315211.1XP_017170700.1  transcription factor IIIB 90 kDa subunit isoform X6

    5. XM_011244184.2XP_011242486.1  transcription factor IIIB 90 kDa subunit isoform X5

      See identical proteins and their annotated locations for XP_011242486.1

      Conserved Domains (2) summary
      pfam07741
      Location:249341
      BRF1; Brf1-like TBP-binding domain
      cl00050
      Location:356
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    6. XM_011244183.2XP_011242485.1  transcription factor IIIB 90 kDa subunit isoform X4

      Conserved Domains (3) summary
      COG1405
      Location:1119
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:306398
      BRF1; Brf1-like TBP-binding domain
      cl00050
      Location:40113
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    7. XM_006516266.2XP_006516329.2  transcription factor IIIB 90 kDa subunit isoform X3

      See identical proteins and their annotated locations for XP_006516329.2

      Conserved Domains (3) summary
      COG1405
      Location:24132
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:319411
      BRF1; Brf1-like TBP-binding domain
      cl00050
      Location:53126
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    8. XM_011244185.2XP_011242487.1  transcription factor IIIB 90 kDa subunit isoform X5

      See identical proteins and their annotated locations for XP_011242487.1

      Conserved Domains (2) summary
      pfam07741
      Location:249341
      BRF1; Brf1-like TBP-binding domain
      cl00050
      Location:356
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    9. XM_006516267.2XP_006516330.1  transcription factor IIIB 90 kDa subunit isoform X5

      See identical proteins and their annotated locations for XP_006516330.1

      Conserved Domains (2) summary
      pfam07741
      Location:249341
      BRF1; Brf1-like TBP-binding domain
      cl00050
      Location:356
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RNA

    1. XR_872720.2 RNA Sequence

    2. XR_381545.3 RNA Sequence

    3. XR_001780489.1 RNA Sequence

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