Format

Send to:

Choose Destination
    • Showing Current items.

    Rusc1 RUN and SH3 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 72296, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rusc1provided by MGI
    Official Full Name
    RUN and SH3 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1919546
    See related
    Ensembl:ENSMUSG00000041263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NESCA; AA408288; 2210403N08Rik
    Expression
    Ubiquitous expression in cortex adult (RPKM 26.5), CNS E18 (RPKM 25.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rusc1 in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88991282..89000670, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89083975..89093363, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (88887899..88897285, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene predicted gene, 26465 Neighboring gene predicted gene, 24403 Neighboring gene predicted gene, 22935 Neighboring gene farnesyl diphosphate synthetase Neighboring gene predicted gene, 29704

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    RUN and SH3 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083807.1NP_001077276.1  RUN and SH3 domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001077276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      BB871992, BC056360
      Consensus CDS
      CCDS38485.1
      UniProtKB/Swiss-Prot
      Q8BG26
      Related
      ENSMUSP00000056640.7, ENSMUST00000052539.13
      Conserved Domains (2) summary
      pfam02759
      Location:523633
      RUN; RUN domain
      cl17036
      Location:839890
      SH3; Src Homology 3 domain superfamily
    2. NM_001083808.1NP_001077277.1  RUN and SH3 domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001077277.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC056360, BY201665
      Consensus CDS
      CCDS50956.1
      UniProtKB/Swiss-Prot
      Q8BG26
      UniProtKB/TrEMBL
      Q3TDG5
      Related
      ENSMUSP00000130477.2, ENSMUST00000166687.6
      Conserved Domains (2) summary
      cl02689
      Location:61171
      RUN; RUN domain
      cl17036
      Location:377428
      SH3; Src Homology 3 domain superfamily
    3. NM_028188.2NP_082464.2  RUN and SH3 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK039664, BB871992, BC056360
      Consensus CDS
      CCDS38486.1
      UniProtKB/Swiss-Prot
      Q8BG26
      Related
      ENSMUSP00000088447.6, ENSMUST00000090929.12
      Conserved Domains (2) summary
      pfam02759
      Location:660770
      RUN; RUN domain
      cl17036
      Location:9761027
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88991282..89000670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502134.5XP_006502197.1  RUN and SH3 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006502197.1

      UniProtKB/Swiss-Prot
      Q8BG26
      UniProtKB/TrEMBL
      Q3TDG5
      Conserved Domains (2) summary
      cl02689
      Location:61171
      RUN; RUN domain
      cl17036
      Location:377428
      SH3; Src Homology 3 domain superfamily
    Support Center