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    Lrrc8e leucine rich repeat containing 8 family, member E [ Mus musculus (house mouse) ]

    Gene ID: 72267, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lrrc8eprovided by MGI
    Official Full Name
    leucine rich repeat containing 8 family, member Eprovided by MGI
    Primary source
    MGI:MGI:1919517
    See related
    Ensembl:ENSMUSG00000046589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C87354; 1810049O03Rik
    Expression
    Biased expression in adrenal adult (RPKM 4.6), bladder adult (RPKM 3.6) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lrrc8e in Genome Data Viewer
    Location:
    8; 8 A1.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4274269..4287470)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4224268..4237470)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (4226827..4237470)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932443L11 gene Neighboring gene ecotropic viral integration site 5 like Neighboring gene proline rich 36 Neighboring gene mitogen-activated protein kinase kinase 7 Neighboring gene transforming growth factor, beta receptor III-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91131

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ion channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    volume-regulated anion channel subunit LRRC8E
    Names
    leucine-rich repeat-containing protein 8E

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028175.2NP_082451.2  volume-regulated anion channel subunit LRRC8E

      See identical proteins and their annotated locations for NP_082451.2

      Status: VALIDATED

      Source sequence(s)
      AC123029, BC080783
      Consensus CDS
      CCDS22079.1
      UniProtKB/Swiss-Prot
      Q66JT1
      Related
      ENSMUSP00000052055.7, ENSMUST00000053035.7
      Conserved Domains (4) summary
      PLN00113
      Location:412756
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:606771
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:559582
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1330
      Pannexin_like; Pannexin-like TM region of LRRC8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      4274269..4287470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242086.4XP_011240388.1  volume-regulated anion channel subunit LRRC8E isoform X1

      See identical proteins and their annotated locations for XP_011240388.1

      UniProtKB/Swiss-Prot
      Q66JT1
      Conserved Domains (4) summary
      PLN00113
      Location:412756
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:606771
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:559582
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1330
      Pannexin_like; Pannexin-like TM region of LRRC8
    2. XM_006508908.3XP_006508971.1  volume-regulated anion channel subunit LRRC8E isoform X2

      Conserved Domains (3) summary
      PLN00113
      Location:37381
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:231396
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:184207
      LRR_RI; leucine-rich repeat [structural motif]
    3. XM_006508907.3XP_006508970.1  volume-regulated anion channel subunit LRRC8E isoform X1

      See identical proteins and their annotated locations for XP_006508970.1

      UniProtKB/Swiss-Prot
      Q66JT1
      Conserved Domains (4) summary
      PLN00113
      Location:412756
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:606771
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:559582
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1330
      Pannexin_like; Pannexin-like TM region of LRRC8
    4. XM_006508906.4XP_006508969.1  volume-regulated anion channel subunit LRRC8E isoform X1

      See identical proteins and their annotated locations for XP_006508969.1

      UniProtKB/Swiss-Prot
      Q66JT1
      Conserved Domains (4) summary
      PLN00113
      Location:412756
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:606771
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:559582
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1330
      Pannexin_like; Pannexin-like TM region of LRRC8
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