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    Mtrex Mtr4 exosome RNA helicase [ Mus musculus (house mouse) ]

    Gene ID: 72198, updated on 12-Aug-2018

    Summary

    Official Symbol
    Mtrexprovided by MGI
    Official Full Name
    Mtr4 exosome RNA helicaseprovided by MGI
    Primary source
    MGI:MGI:1919448
    See related
    Ensembl:ENSMUSG00000016018
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Skiv2l2; mKIAA0052; 2610528A15Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 25.7), CNS E14 (RPKM 16.5) and 24 other tissues See more
    Orthologs

    Genomic context

    See Mtrex in Genome Data Viewer
    Location:
    13; 13 D2.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (112867780..112927380, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (113657988..113717588, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 38, member 9 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene predicted gene, 41067 Neighboring gene phospholipid phosphatase 1 Neighboring gene 40S ribosomal protein S13-like Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 29 Neighboring gene cyclin O

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    maturation of 5.8S rRNA ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    TRAMP complex ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    exosome RNA helicase MTR4
    Names
    ATP-dependent helicase SKIV2L2
    TRAMP-like complex helicase
    superkiller viralicidic activity 2-like 2
    NP_082427.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028151.2NP_082427.1  exosome RNA helicase MTR4

      See identical proteins and their annotated locations for NP_082427.1

      Status: PROVISIONAL

      Source sequence(s)
      AC165265
      Consensus CDS
      CCDS26778.1
      UniProtKB/Swiss-Prot
      Q9CZU3
      Related
      ENSMUSP00000022281.3, ENSMUST00000022281.4
      Conserved Domains (5) summary
      COG4581
      Location:921040
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      cd00079
      Location:372536
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:142285
      DEAD; DEAD/DEAH box helicase
      pfam08148
      Location:8661033
      DSHCT; DSHCT (NUC185) domain
      pfam13234
      Location:582838
      rRNA_proc-arch; rRNA-processing arch domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      112867780..112927380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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