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    Adpgk ADP-dependent glucokinase [ Mus musculus (house mouse) ]

    Gene ID: 72141, updated on 31-Jan-2019

    Summary

    Official Symbol
    Adpgkprovided by MGI
    Official Full Name
    ADP-dependent glucokinaseprovided by MGI
    Primary source
    MGI:MGI:1919391
    See related
    Ensembl:ENSMUSG00000025236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adp-gk; C77577; 2610017G09Rik
    Expression
    Ubiquitous expression in liver E18 (RPKM 16.1), limb E14.5 (RPKM 15.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Adpgk in Genome Data Viewer
    Location:
    9; 9 B
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (59291545..59316200)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (59139379..59164007)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33053 Neighboring gene predicted gene, 39345 Neighboring gene Bardet-Biedl syndrome 4 (human) Neighboring gene ariadne RBR E3 ubiquitin protein ligase 1 Neighboring gene ribosomal protein S11, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP-specific glucokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ADP-specific glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ADP-dependent glucokinase
    Names
    ATP-dependent glucokinase
    NP_082397.1
    XP_006511529.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359282.1NP_001346211.1  ADP-dependent glucokinase isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant (1), encodes a protein (isoform 2) that is one amino acid shorter, compared to isoform 1.
      Source sequence(s)
      BC094657, CT025587
      Conserved Domains (1) summary
      cd01938
      Location:60491
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
    2. NM_028121.2NP_082397.1  ADP-dependent glucokinase isoform 1 precursor

      See identical proteins and their annotated locations for NP_082397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK011434, AK048904, BC094657
      Consensus CDS
      CCDS23248.1
      UniProtKB/Swiss-Prot
      Q8VDL4
      UniProtKB/TrEMBL
      A0A1L1SSF2
      Related
      ENSMUSP00000149882.1, ENSMUST00000217570.1
      Conserved Domains (1) summary
      cd01938
      Location:60492
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      59291545..59316200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511466.2XP_006511529.1  ADP-dependent glucokinase isoform X1

      UniProtKB/TrEMBL
      Q3UDS7
      Related
      ENSMUSP00000026266.8, ENSMUST00000026266.8
      Conserved Domains (1) summary
      cd01938
      Location:60491
      ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
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