Format

Send to:

Choose Destination
    • Showing Current items.

    Cnot2 CCR4-NOT transcription complex, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 72068, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cnot2provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 2provided by MGI
    Primary source
    MGI:MGI:1919318
    See related
    Ensembl:ENSMUSG00000020166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C79650; AA537049; AA959607; AW557563; 2600016M12Rik; 2810470K03Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.3), CNS E11.5 (RPKM 10.3) and 27 other tissues See more
    Orthologs

    Genomic context

    See Cnot2 in Genome Data Viewer
    Location:
    10; 10 D2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (116485161..116581536, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (115922217..116018567, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 1 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 2 Neighboring gene predicted gene, 31593 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene predicted gene, 26579

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC115808

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cytoplasmic mRNA processing body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of stem cell population maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 2
    Names
    CCR4-associated factor 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037846.3NP_001032935.2  CCR4-NOT transcription complex subunit 2 isoform a

      See identical proteins and their annotated locations for NP_001032935.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AK078121, BB353467, BC065171, BM245866
      Consensus CDS
      CCDS36064.1
      UniProtKB/Swiss-Prot
      Q8C5L3
      Related
      ENSMUSP00000100902.1, ENSMUST00000105267.7
      Conserved Domains (1) summary
      pfam04153
      Location:396519
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    2. NM_001037847.2NP_001032936.2  CCR4-NOT transcription complex subunit 2 isoform d

      See identical proteins and their annotated locations for NP_001032936.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in its 5' coding region and uses an upstream translation start codon, compared to variant 1. The resulting isoform (d) is longer at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK078121, BB353467, BC065171, BM245866
      UniProtKB/Swiss-Prot
      Q8C5L3
      UniProtKB/TrEMBL
      A0A1S6GWJ6
      Conserved Domains (1) summary
      pfam04153
      Location:406529
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    3. NM_001037848.3NP_001032937.1  CCR4-NOT transcription complex subunit 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR, lacks several exons in the 3' coding region, and includes an alternate terminal exon, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC139376, AK078121, BC065171, BG067916
      Consensus CDS
      CCDS36065.1
      UniProtKB/Swiss-Prot
      Q8C5L3
      UniProtKB/TrEMBL
      H7BWX6
      Related
      ENSMUSP00000020374.5, ENSMUST00000020374.5
    4. NM_001359247.1NP_001346176.1  CCR4-NOT transcription complex subunit 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC139376, AK078121, BB353467, BC043133, BC065171, CD578905
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    5. NM_001359248.1NP_001346177.1  CCR4-NOT transcription complex subunit 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC139376, AK078121, BB353467, BC043133, BC065171, CX562783
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    6. NM_001359249.1NP_001346178.1  CCR4-NOT transcription complex subunit 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC139376, AK011231, AK078121, BB353467, BC043133, BC065171, CD578905
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    7. NM_001359250.1NP_001346179.1  CCR4-NOT transcription complex subunit 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC139376, AK078121, BB353467, BC043133, BC065171, CX562783
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    8. NM_001359251.1NP_001346180.1  CCR4-NOT transcription complex subunit 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC139376, AK011231, AK078121, BB353467, BC043133, BC065171, CD578905
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    9. NM_001359252.1NP_001346181.1  CCR4-NOT transcription complex subunit 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC139376, AK078121, BB353467, BC043133, BC065171, CD578905, CX562783
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    10. NM_001359253.1NP_001346182.1  CCR4-NOT transcription complex subunit 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC139376, AK078121, BB353467, BC043133, CX562783
      Conserved Domains (1) summary
      pfam04153
      Location:206329
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    11. NM_001359563.1NP_001346492.1  CCR4-NOT transcription complex subunit 2 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC139376, AI428917, AK011231, BC065171
      Conserved Domains (1) summary
      pfam04153
      Location:311434
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    12. NM_028082.2NP_082358.2  CCR4-NOT transcription complex subunit 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform 1.
      Source sequence(s)
      AK078121, BB345568, BC065171, BC090624
      Consensus CDS
      CCDS24185.2
      UniProtKB/Swiss-Prot
      Q8C5L3
      UniProtKB/TrEMBL
      E9Q027, Q5CZY5
      Related
      ENSMUSP00000132315.1, ENSMUST00000168036.7
      Conserved Domains (1) summary
      pfam04153
      Location:355478
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      116485161..116581536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514189.3XP_006514252.1  CCR4-NOT transcription complex subunit 2 isoform X9

      Conserved Domains (1) summary
      pfam04153
      Location:218341
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    2. XM_006514190.3XP_006514253.1  CCR4-NOT transcription complex subunit 2 isoform X10

      See identical proteins and their annotated locations for XP_006514253.1

      Conserved Domains (1) summary
      pfam04153
      Location:206329
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    3. XM_006514183.3XP_006514246.1  CCR4-NOT transcription complex subunit 2 isoform X5

      See identical proteins and their annotated locations for XP_006514246.1

      UniProtKB/Swiss-Prot
      Q8C5L3
      Related
      ENSMUSP00000100900.1, ENSMUST00000105265.7
      Conserved Domains (1) summary
      pfam04153
      Location:311434
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    4. XM_006514188.3XP_006514251.1  CCR4-NOT transcription complex subunit 2 isoform X7

      Conserved Domains (1) summary
      pfam04153
      Location:259382
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    5. XM_017314112.1XP_017169601.1  CCR4-NOT transcription complex subunit 2 isoform X10

      Conserved Domains (1) summary
      pfam04153
      Location:206329
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    6. XM_017314111.1XP_017169600.1  CCR4-NOT transcription complex subunit 2 isoform X8

    7. XM_006514177.3XP_006514240.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    8. XM_017314107.1XP_017169596.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    9. XM_017314106.1XP_017169595.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    10. XM_006514174.3XP_006514237.1  CCR4-NOT transcription complex subunit 2 isoform X3

      See identical proteins and their annotated locations for XP_006514237.1

      Conserved Domains (1) summary
      pfam04153
      Location:365488
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    11. XM_006514186.3XP_006514249.1  CCR4-NOT transcription complex subunit 2 isoform X6

      Conserved Domains (1) summary
      pfam04153
      Location:269392
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    12. XM_006514182.3XP_006514245.1  CCR4-NOT transcription complex subunit 2 isoform X4

      Conserved Domains (1) summary
      pfam04153
      Location:376499
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    13. XM_006514181.1XP_006514244.1  CCR4-NOT transcription complex subunit 2 isoform X2

      See identical proteins and their annotated locations for XP_006514244.1

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    14. XM_006514180.1XP_006514243.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    15. XM_006514184.3XP_006514247.1  CCR4-NOT transcription complex subunit 2 isoform X5

      See identical proteins and their annotated locations for XP_006514247.1

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:311434
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    16. XM_006514191.1XP_006514254.1  CCR4-NOT transcription complex subunit 2 isoform X10

      See identical proteins and their annotated locations for XP_006514254.1

      Conserved Domains (1) summary
      pfam04153
      Location:206329
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    17. XM_017314109.1XP_017169598.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    18. XM_006514175.3XP_006514238.1  CCR4-NOT transcription complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006514238.1

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:396519
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    19. XM_006514179.3XP_006514242.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    20. XM_017314108.1XP_017169597.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8C5L3
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    21. XM_017314113.1XP_017169602.1  CCR4-NOT transcription complex subunit 2 isoform X10

      Conserved Domains (1) summary
      pfam04153
      Location:206329
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    Support Center