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    CCT3 chaperonin containing TCP1 subunit 3 [ Homo sapiens (human) ]

    Gene ID: 7203, updated on 5-Aug-2018

    Summary

    Official Symbol
    CCT3provided by HGNC
    Official Full Name
    chaperonin containing TCP1 subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:1616
    See related
    Ensembl:ENSG00000163468 MIM:600114; Vega:OTTHUMG00000024061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCTG; PIG48; TRIC5; CCT-gamma; TCP-1-gamma
    Summary
    The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in testis (RPKM 72.7), adrenal (RPKM 56.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See CCT3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (156308961..156338415, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156278752..156308206, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glycosylated lysosomal membrane protein Neighboring gene VHL like Neighboring gene TSSK6 activating cochaperone Neighboring gene Rh family B glycoprotein (gene/pseudogene) Neighboring gene chromosome 1 open reading frame 61 Neighboring gene microRNA 9-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    NHGRI GWA Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    NHGRI GWA Catalog
    Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif interacts with CCT3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperonin-containing T-complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    zona pellucida receptor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    T-complex protein 1 subunit gamma
    Names
    T-complex protein 1, gamma subunit
    TCP1 (t-complex-1) ring complex, polypeptide 5
    chaperonin containing TCP1, subunit 3 (gamma)
    hTRiC5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008800.2NP_001008800.1  T-complex protein 1 subunit gamma isoform c

      See identical proteins and their annotated locations for NP_001008800.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AK126400, AK293477, BG476176
      Consensus CDS
      CCDS30888.1
      UniProtKB/Swiss-Prot
      P49368
      UniProtKB/TrEMBL
      B3KX11
      Related
      ENSP00000357242.2, OTTHUMP00000231494, ENST00000368259.6, OTTHUMT00000387013
      Conserved Domains (2) summary
      cd03337
      Location:6487
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02344
      Location:6491
      chap_CCT_gamma; T-complex protein 1, gamma subunit
    2. NM_005998.4NP_005989.3  T-complex protein 1 subunit gamma isoform a

      See identical proteins and their annotated locations for NP_005989.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AB208882, AK126400, BG476176
      Consensus CDS
      CCDS1140.2
      UniProtKB/Swiss-Prot
      P49368
      UniProtKB/TrEMBL
      B3KX11, Q59H77
      Related
      ENSP00000295688.3, OTTHUMP00000025735, ENST00000295688.7, OTTHUMT00000060602
      Conserved Domains (2) summary
      cd03337
      Location:6525
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02344
      Location:6529
      chap_CCT_gamma; T-complex protein 1, gamma subunit

    RNA

    1. NR_036564.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK126400, AK300765, BG476176
      Related
      ENST00000368262.7, OTTHUMT00000387015
    2. NR_036565.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK126400, AK316387, BG476176
      Related
      ENST00000472765.6, OTTHUMT00000060605

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      156308961..156338415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008883.1: Suppressed sequence

      Description
      NM_001008883.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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