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    Fundc1 FUN14 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 72018, updated on 12-Mar-2019

    Summary

    Official Symbol
    Fundc1provided by MGI
    Official Full Name
    FUN14 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1919268
    See related
    Ensembl:ENSMUSG00000025040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500005J14Rik; 1810033P05Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.0), frontal lobe adult (RPKM 6.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See Fundc1 in Genome Data Viewer
    Location:
    X; X A1.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (17519967..17572325, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (17133695..17149423, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene EF-hand domain (C-terminal) containing 2 Neighboring gene predicted gene, 35105 Neighboring gene TatD DNase domain containing 2 pseudogene Neighboring gene predicted gene, 39497 Neighboring gene predicted pseudogene 5073 Neighboring gene heat shock protein 8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    • Mitophagy - animal, organism-specific biosystem (from KEGG)
      Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Mitophagy - animal, conserved biosystem (from KEGG)
      Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to organonitrogen compound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    FUN14 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313745.1NP_001300674.1  FUN14 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK005163, BM934468, BX005345
      Consensus CDS
      CCDS85750.1
      UniProtKB/Swiss-Prot
      Q9DB70
      UniProtKB/TrEMBL
      H3BJZ1
      Related
      ENSMUSP00000135183.1, ENSMUST00000176638.7
      Conserved Domains (1) summary
      pfam04930
      Location:54110
      FUN14; FUN14 family
    2. NM_001313746.1NP_001300675.1  FUN14 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BM934468, BX005345, BY061369, CD805077
      Consensus CDS
      CCDS85749.1
      UniProtKB/TrEMBL
      H3BJ77
      Related
      ENSMUSP00000135026.1, ENSMUST00000142638.1
      Conserved Domains (1) summary
      pfam04930
      Location:11110
      FUN14; FUN14 family
    3. NM_028058.4NP_082334.1  FUN14 domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_082334.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK005163, BM934468, BX005345
      Consensus CDS
      CCDS30035.1
      UniProtKB/Swiss-Prot
      Q9DB70
      Related
      ENSMUSP00000026016.6, ENSMUST00000026016.12
      Conserved Domains (1) summary
      pfam04930
      Location:54153
      FUN14; FUN14 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      17519967..17572325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247496.2XP_011245798.1  FUN14 domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam04930
      Location:5493
      FUN14; FUN14 family
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