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    TRHR thyrotropin releasing hormone receptor [ Homo sapiens (human) ]

    Gene ID: 7201, updated on 8-Jul-2021

    Summary

    Official Symbol
    TRHRprovided by HGNC
    Official Full Name
    thyrotropin releasing hormone receptorprovided by HGNC
    Primary source
    HGNC:HGNC:12299
    See related
    Ensembl:ENSG00000174417 MIM:188545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHNG7; TRH-R
    Summary
    This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See TRHR in Genome Data Viewer
    Location:
    8q23.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (109086585..109121565)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (110098814..110133794)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927413 Neighboring gene uncharacterized LOC107984017 Neighboring gene NudC domain containing 1 Neighboring gene ENY2 transcription and export complex 2 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.
    GeneReviews: Not available
    Hypothyroidism, congenital, nongoitrous, 7
    MedGen: CN295006 OMIM: 618573 GeneReviews: Not available
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    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of thyrotropin-releasing hormone receptor (TRHR) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC141920

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thyrotropin-releasing hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    thyrotropin-releasing hormone receptor
    Names
    thyroliberin receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017161.1 RefSeqGene

      Range
      4182..39119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003301.7NP_003292.1  thyrotropin-releasing hormone receptor

      See identical proteins and their annotated locations for NP_003292.1

      Status: VALIDATED

      Source sequence(s)
      AC104945
      Consensus CDS
      CCDS6311.1
      UniProtKB/Swiss-Prot
      P34981
      Related
      ENSP00000430711.2, ENST00000518632.2
      Conserved Domains (1) summary
      cd14995
      Location:26331
      7tmA_TRH-R; thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      109086585..109121565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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