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    Ddx28 DEAD box helicase 28 [ Mus musculus (house mouse) ]

    Gene ID: 71986, updated on 18-Sep-2024

    Summary

    Official Symbol
    Ddx28provided by MGI
    Official Full Name
    DEAD box helicase 28provided by MGI
    Primary source
    MGI:MGI:1919236
    See related
    Ensembl:ENSMUSG00000045538 AllianceGenome:MGI:1919236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mddx28; 2410004K13Rik
    Summary
    Predicted to enable rRNA binding activity. Predicted to be involved in mitochondrial large ribosomal subunit assembly. Predicted to act upstream of or within ribosome biogenesis. Located in mitochondrion. Orthologous to human DDX28 (DEAD-box helicase 28). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See Ddx28 in Genome Data Viewer
    Location:
    8 D3; 8 53.08 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106736248..106738118, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106009616..106011486, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45752 Neighboring gene dipeptidase 3 Neighboring gene predicted gene, 22972 Neighboring gene dipeptidase 2 Neighboring gene dihydrouridine synthase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1375 Neighboring gene STARR-positive B cell enhancer ABC_E3801 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108636517-108636718 Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene epithelial splicing regulatory protein 2

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial large ribosomal subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial large ribosomal subunit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial large ribosomal subunit assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX28
    Names
    ATP-dependent RNA helicase Ddx28
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28
    mitochondrial DEAD box protein 28
    NP_082314.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028038.3NP_082314.2  probable ATP-dependent RNA helicase DDX28

      See identical proteins and their annotated locations for NP_082314.2

      Status: VALIDATED

      Source sequence(s)
      AC133499, AK163480, BC120582
      Consensus CDS
      CCDS22626.1
      UniProtKB/Swiss-Prot
      Q0VBM0, Q3TQM0, Q9CWT6
      Related
      ENSMUSP00000058950.6, ENSMUST00000058579.7
      Conserved Domains (3) summary
      PRK01297
      Location:28539
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      pfam00271
      Location:376492
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:128343
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106736248..106738118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)