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    Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha [ Mus musculus (house mouse) ]

    Gene ID: 71978, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ppp2r2aprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B, alphaprovided by MGI
    Primary source
    MGI:MGI:1919228
    See related
    Ensembl:ENSMUSG00000022052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1541; 2410004D02Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 26.6), CNS E11.5 (RPKM 11.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Ppp2r2a in Genome Data Viewer
    Location:
    14; 14 D1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (67251505..67309920, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (67014056..67072471, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (67634508..67691266, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24258 Neighboring gene BCL2/adenovirus E1B interacting protein 3-like Neighboring gene predicted gene, 52123 Neighboring gene predicted gene, 30438

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in peptidyl-serine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to morphine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    NP_001192117.1
    NP_001346962.1
    NP_001346963.1
    NP_082308.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205188.1NP_001192117.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2

      See identical proteins and their annotated locations for NP_001192117.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC165148, AK010380, BC065100, CT030233
      Consensus CDS
      CCDS88697.1
      UniProtKB/Swiss-Prot
      Q6P1F6
      UniProtKB/TrEMBL
      Q9CWU3
      Related
      ENSMUSP00000153191.2, ENSMUST00000225380.2
      Conserved Domains (2) summary
      sd00039
      Location:3179
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:29327
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001360033.1NP_001346962.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA185461, AC165148, AK161507, BC065100, CT030233
      Conserved Domains (2) summary
      COG5170
      Location:2283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:2157
      7WD40; WD40 repeat [structural motif]
    3. NM_001360034.1NP_001346963.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165148, AK161507, BC065100, CT030233
      Conserved Domains (2) summary
      COG5170
      Location:2283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:2157
      7WD40; WD40 repeat [structural motif]
    4. NM_028032.3NP_082308.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

      See identical proteins and their annotated locations for NP_082308.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC165148, AK161507, BC065100, CT030233
      Consensus CDS
      CCDS56967.1
      UniProtKB/Swiss-Prot
      Q6P1F6
      UniProtKB/TrEMBL
      Q3TT94
      Related
      ENSMUSP00000086640.6, ENSMUST00000089230.7
      Conserved Domains (2) summary
      COG5170
      Location:7442
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:3179
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      67251505..67309920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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