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    Wdr73 WD repeat domain 73 [ Mus musculus (house mouse) ]

    Gene ID: 71968, updated on 23-Jun-2021

    Summary

    Official Symbol
    Wdr73provided by MGI
    Official Full Name
    WD repeat domain 73provided by MGI
    Primary source
    MGI:MGI:1919218
    See related
    Ensembl:ENSMUSG00000025722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C85352; AI848574; 1200011I23Rik; 2410008B13Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.9), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Wdr73 in Genome Data Viewer
    Location:
    7; 7 D3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80540471..80551017, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80890723..80901269, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (88035609..88046155, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene VISTA enhancer mm170 Neighboring gene zinc finger and SCAN domain containing 2 Neighboring gene predicted gene, 32112 Neighboring gene predicted gene, 51451 Neighboring gene neuromedin B Neighboring gene SEC11 homolog A, signal peptidase complex subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleus organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WD repeat-containing protein 73

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028026.2NP_082302.2  WD repeat-containing protein 73

      See identical proteins and their annotated locations for NP_082302.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AK010448, AK169377, AK169527, BM940898
      Consensus CDS
      CCDS52282.1
      UniProtKB/Swiss-Prot
      Q9CWR1
      Related
      ENSMUSP00000026816.9, ENSMUST00000026816.15
      Conserved Domains (3) summary
      COG2319
      Location:238364
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:279322
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:238364
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_027976.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123744, AK169377, BC068122
      Related
      ENSMUST00000139990.8
    2. NR_152100.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences at the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123744
    3. NR_152101.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123744

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80540471..80551017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153449.1XP_036009342.1  WD repeat-containing protein 73 isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:129255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170213
      7WD40; WD40 repeat [structural motif]
    2. XM_036153447.1XP_036009340.1  WD repeat-containing protein 73 isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:129255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170213
      7WD40; WD40 repeat [structural motif]
    3. XM_036153448.1XP_036009341.1  WD repeat-containing protein 73 isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:129255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170213
      7WD40; WD40 repeat [structural motif]
    4. XM_006541206.1XP_006541269.1  WD repeat-containing protein 73 isoform X1

      See identical proteins and their annotated locations for XP_006541269.1

      UniProtKB/Swiss-Prot
      Q9CWR1
      Conserved Domains (2) summary
      COG2319
      Location:129255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170213
      7WD40; WD40 repeat [structural motif]
    5. XM_006541209.1XP_006541272.1  WD repeat-containing protein 73 isoform X1

      See identical proteins and their annotated locations for XP_006541272.1

      UniProtKB/Swiss-Prot
      Q9CWR1
      Conserved Domains (2) summary
      COG2319
      Location:129255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170213
      7WD40; WD40 repeat [structural motif]
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