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    Castor1 cytosolic arginine sensor for mTORC1 subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 71962, updated on 23-Jun-2021

    Summary

    Official Symbol
    Castor1provided by MGI
    Official Full Name
    cytosolic arginine sensor for mTORC1 subunit 1provided by MGI
    Primary source
    MGI:MGI:1919212
    See related
    Ensembl:ENSMUSG00000020424
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gat; Gatsl3; 2410008K03Rik
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 12.0), lung adult (RPKM 10.7) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Castor1 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4167401..4172409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4218166..4222409)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4118254..4122412)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 157 Neighboring gene splicing factor 3a, subunit 1 Neighboring gene TBC1 domain family, member 10a Neighboring gene predicted gene 11956 Neighboring gene oncostatin M

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC141006

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arginine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables arginine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to L-arginine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to L-arginine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of GATOR2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytosolic arginine sensor for mTORC1 subunit 1
    Names
    GATS protein-like 3
    GATS-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028022.2NP_082298.1  cytosolic arginine sensor for mTORC1 subunit 1

      See identical proteins and their annotated locations for NP_082298.1

      Status: VALIDATED

      Source sequence(s)
      AK010455, BC039988, CN719833
      Consensus CDS
      CCDS24381.1
      UniProtKB/Swiss-Prot
      Q9CWQ8
      Related
      ENSMUSP00000020699.4, ENSMUST00000020699.4
      Conserved Domains (1) summary
      pfam13840
      Location:260321
      ACT_7; ACT domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4167401..4172409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157005.1XP_036012898.1  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1

      Conserved Domains (2) summary
      pfam13840
      Location:204268
      ACT_7; ACT domain
      pfam18700
      Location:116
      Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain
    2. XM_011243752.4XP_011242054.1  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1

      Conserved Domains (2) summary
      pfam13840
      Location:204268
      ACT_7; ACT domain
      pfam18700
      Location:116
      Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain
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