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    Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 71954, updated on 27-Nov-2024

    Summary

    Official Symbol
    Suds3provided by MGI
    Official Full Name
    suppressor of defective silencing 3 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1919204
    See related
    Ensembl:ENSMUSG00000066900 AllianceGenome:MGI:1919204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mSds3; 2400003N08Rik; 2410008L21Rik
    Summary
    Enables histone deacetylase binding activity and identical protein binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within blastocyst hatching. Part of Sin3-type complex. Is expressed in early conceptus; ovary; secondary oocyte; and seminiferous cord. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 43.8), ovary adult (RPKM 42.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Suds3 in Genome Data Viewer
    Location:
    5 F; 5 56.88 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117229743..117257980, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117091678..117115993, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7478 Neighboring gene predicted gene, 42011 Neighboring gene STARR-positive B cell enhancer ABC_E3606 Neighboring gene STARR-positive B cell enhancer ABC_E2172 Neighboring gene STARR-seq mESC enhancer starr_14168 Neighboring gene STARR-positive B cell enhancer ABC_E6369 Neighboring gene TAO kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3607 Neighboring gene STARR-positive B cell enhancer ABC_E3608 Neighboring gene STARR-positive B cell enhancer ABC_E3609 Neighboring gene STARR-seq mESC enhancer starr_14169 Neighboring gene STARR-positive B cell enhancer ABC_E8074 Neighboring gene phosphatidylethanolamine binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Sin3-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    sin3 histone deacetylase corepressor complex component SDS3
    Names
    suppressor of defective silencing 3 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122666.2NP_001116138.1  sin3 histone deacetylase corepressor complex component SDS3 isoform b

      See identical proteins and their annotated locations for NP_001116138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the shorter transcript and encodes the longer isoform (b).
      Source sequence(s)
      AV338433, BC055764, BC062176, CJ094124
      Consensus CDS
      CCDS51631.1
      UniProtKB/TrEMBL
      A0A0R4J243
      Related
      ENSMUSP00000130535.2, ENSMUST00000166397.3
      Conserved Domains (1) summary
      pfam08598
      Location:62178
      Sds3; Sds3-like
    2. NM_178622.5NP_848737.3  sin3 histone deacetylase corepressor complex component SDS3 isoform a

      See identical proteins and their annotated locations for NP_848737.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' coding region and the 3' UTR, compared to variant 2. It encodes isoform a, which has a shorter and distinct C-terminus, compared to isoform b.
      Source sequence(s)
      AV338433, BC055764, CJ094124
      Consensus CDS
      CCDS39232.1
      UniProtKB/Swiss-Prot
      Q3UC92, Q6P6K1, Q7TNT0, Q8BR65, Q8BRR7, Q8K5B4
      Related
      ENSMUSP00000083662.6, ENSMUST00000086471.12
      Conserved Domains (1) summary
      pfam08598
      Location:62178
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      117229743..117257980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165504.1XP_036021397.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X1