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    Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 71954, updated on 2-Oct-2018

    Summary

    Official Symbol
    Suds3provided by MGI
    Official Full Name
    suppressor of defective silencing 3 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1919204
    See related
    Ensembl:ENSMUSG00000066900 Vega:OTTMUSG00000056114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mSds3; AU067672; 2400003N08Rik; 2410008L21Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 43.8), ovary adult (RPKM 42.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Suds3 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (117091678..117115993, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (117541689..117566002, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene 7478 Neighboring gene predicted gene, 42011 Neighboring gene TAO kinase 3 Neighboring gene phosphatidylethanolamine binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Sin3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sin3 histone deacetylase corepressor complex component SDS3
    Names
    suppressor of defective silencing 3 protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122666.2NP_001116138.1  sin3 histone deacetylase corepressor complex component SDS3 isoform b

      See identical proteins and their annotated locations for NP_001116138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the shorter transcript and encodes the longer isoform (b).
      Source sequence(s)
      AV338433, BC055764, BC062176, CJ094124
      Consensus CDS
      CCDS51631.1
      UniProtKB/Swiss-Prot
      Q8BR65
      UniProtKB/TrEMBL
      A0A0R4J243
      Related
      ENSMUSP00000130535.1, OTTMUSP00000072914, ENSMUST00000166397.2, OTTMUST00000138765
      Conserved Domains (1) summary
      pfam08598
      Location:62178
      Sds3; Sds3-like
    2. NM_178622.5NP_848737.3  sin3 histone deacetylase corepressor complex component SDS3 isoform a

      See identical proteins and their annotated locations for NP_848737.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' coding region and the 3' UTR, compared to variant 2. It encodes isoform a, which has a shorter and distinct C-terminus, compared to isoform b.
      Source sequence(s)
      AV338433, BC055764, CJ094124
      Consensus CDS
      CCDS39232.1
      UniProtKB/Swiss-Prot
      Q8BR65
      Related
      ENSMUSP00000083662.5, OTTMUSP00000072913, ENSMUST00000086471.11, OTTMUST00000138764
      Conserved Domains (1) summary
      pfam08598
      Location:62178
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      117091678..117115993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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