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    Mad2l2 MAD2 mitotic arrest deficient-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 71890, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mad2l2provided by MGI
    Official Full Name
    MAD2 mitotic arrest deficient-like 2provided by MGI
    Primary source
    MGI:MGI:1919140
    See related
    Ensembl:ENSMUSG00000029003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RE; rep; MAD2; REV7; MAD2B; repro22; G1-453-4; 2310033C13Rik
    Expression
    Broad expression in testis adult (RPKM 68.8), CNS E14 (RPKM 17.7) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mad2l2 in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148214615..148230161)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148130158..148145704)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (147514599..147519805)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13201 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2, pseudogene Neighboring gene angiotensin II, type I receptor-associated protein Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene microRNA 7022 Neighboring gene F-box protein 6 Neighboring gene F-box protein 44 Neighboring gene F-box protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction resulting in transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by competitive promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of isotype switching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of zeta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitotic spindle assembly checkpoint protein MAD2B
    Names
    MAD2-like protein 2
    mitotic arrest deficient 2-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305420.1NP_001292349.1  mitotic spindle assembly checkpoint protein MAD2B

      See identical proteins and their annotated locations for NP_001292349.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK009587, AL606929, CO043741
      Consensus CDS
      CCDS18932.1
      UniProtKB/Swiss-Prot
      Q9D752
      Related
      ENSMUSP00000081146.3, ENSMUST00000084129.9
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    2. NM_027985.3NP_082261.2  mitotic spindle assembly checkpoint protein MAD2B

      See identical proteins and their annotated locations for NP_082261.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK009587, AK150216, CO043741
      Consensus CDS
      CCDS18932.1
      UniProtKB/Swiss-Prot
      Q9D752
      Related
      ENSMUSP00000030860.3, ENSMUST00000030860.9
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148214615..148230161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253789.1XP_030109649.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    2. XM_006539187.3XP_006539250.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      See identical proteins and their annotated locations for XP_006539250.1

      UniProtKB/Swiss-Prot
      Q9D752
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    3. XM_030253798.2XP_030109658.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    4. XM_006539183.3XP_006539246.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      See identical proteins and their annotated locations for XP_006539246.1

      UniProtKB/Swiss-Prot
      Q9D752
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    5. XM_030253794.2XP_030109654.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    6. XM_006539186.3XP_006539249.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      See identical proteins and their annotated locations for XP_006539249.1

      UniProtKB/Swiss-Prot
      Q9D752
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    7. XM_030253797.2XP_030109657.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    8. XM_030253791.1XP_030109651.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    9. XM_030253788.2XP_030109648.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    10. XM_006539189.4XP_006539252.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      See identical proteins and their annotated locations for XP_006539252.1

      UniProtKB/TrEMBL
      A2A7G7
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    11. XM_030253795.2XP_030109655.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    12. XM_030253792.2XP_030109652.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    13. XM_030253799.2XP_030109659.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      Related
      ENSMUSP00000101332.2, ENSMUST00000105707.2
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    14. XM_030253796.1XP_030109656.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    15. XM_030253793.2XP_030109653.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    16. XM_006539188.3XP_006539251.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      See identical proteins and their annotated locations for XP_006539251.1

      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    17. XM_030253790.2XP_030109650.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      Related
      ENSMUSP00000122774.2, ENSMUST00000132698.8
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain

    RNA

    1. XR_004941965.1 RNA Sequence

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