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    Mad2l2 MAD2 mitotic arrest deficient-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 71890, updated on 18-Jun-2024

    Summary

    Official Symbol
    Mad2l2provided by MGI
    Official Full Name
    MAD2 mitotic arrest deficient-like 2provided by MGI
    Primary source
    MGI:MGI:1919140
    See related
    Ensembl:ENSMUSG00000029003 AllianceGenome:MGI:1919140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    REV7; MAD2B; repro22; G1-453-4; 2310033C13Rik
    Summary
    Predicted to enable JUN kinase binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including negative regulation of cell-cell adhesion mediated by cadherin; regulation of nucleobase-containing compound metabolic process; and regulation of protein metabolic process. Predicted to act upstream of or within DNA repair and cell division. Predicted to be located in cytosol; nucleolus; and spindle. Predicted to be part of anaphase-promoting complex and zeta DNA polymerase complex. Is expressed in several structures, including brain; ganglia; genitourinary system; intestine; and olfactory epithelium. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group V. Orthologous to human MAD2L2 (mitotic arrest deficient 2 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 68.8), CNS E14 (RPKM 17.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mad2l2 in Genome Data Viewer
    Location:
    4 E2; 4 78.67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148214615..148230161)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148130158..148145704)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13201 Neighboring gene STARR-positive B cell enhancer ABC_E6283 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4727 Neighboring gene STARR-seq mESC enhancer starr_12067 Neighboring gene angiotensin II, type I receptor-associated protein Neighboring gene STARR-seq mESC enhancer starr_12068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:147472153-147472360 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene STARR-positive B cell enhancer ABC_E2146 Neighboring gene STARR-positive B cell enhancer ABC_E4728 Neighboring gene microRNA 7022 Neighboring gene F-box protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E3553 Neighboring gene F-box protein 44 Neighboring gene F-box protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response, signal transduction resulting in transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by competitive promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair via nonhomologous end joining NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of isotype switching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in somatic diversification of immunoglobulins involved in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in telomere maintenance in response to DNA damage NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromatin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of zeta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitotic spindle assembly checkpoint protein MAD2B
    Names
    MAD2-like protein 2
    mitotic arrest deficient 2-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305420.1NP_001292349.1  mitotic spindle assembly checkpoint protein MAD2B

      See identical proteins and their annotated locations for NP_001292349.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK009587, AL606929, CO043741
      Consensus CDS
      CCDS18932.1
      UniProtKB/Swiss-Prot
      Q3TMY6, Q91VP1, Q9D752
      UniProtKB/TrEMBL
      A2A7G6
      Related
      ENSMUSP00000081146.3, ENSMUST00000084129.9
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    2. NM_027985.3NP_082261.2  mitotic spindle assembly checkpoint protein MAD2B

      See identical proteins and their annotated locations for NP_082261.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK009587, AK150216, CO043741
      Consensus CDS
      CCDS18932.1
      UniProtKB/Swiss-Prot
      Q3TMY6, Q91VP1, Q9D752
      UniProtKB/TrEMBL
      A2A7G6
      Related
      ENSMUSP00000030860.3, ENSMUST00000030860.9
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148214615..148230161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253789.1XP_030109649.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      UniProtKB/Swiss-Prot
      Q3TMY6, Q91VP1, Q9D752
      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    2. XM_006539187.3XP_006539250.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      See identical proteins and their annotated locations for XP_006539250.1

      UniProtKB/Swiss-Prot
      Q3TMY6, Q91VP1, Q9D752
      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    3. XM_030253798.2XP_030109658.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      UniProtKB/TrEMBL
      A2A7G6, A2A7G7
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    4. XM_006539183.3XP_006539246.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      See identical proteins and their annotated locations for XP_006539246.1

      UniProtKB/Swiss-Prot
      Q3TMY6, Q91VP1, Q9D752
      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    5. XM_030253794.2XP_030109654.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    6. XM_006539186.3XP_006539249.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      See identical proteins and their annotated locations for XP_006539249.1

      UniProtKB/Swiss-Prot
      Q3TMY6, Q91VP1, Q9D752
      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    7. XM_030253797.2XP_030109657.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      UniProtKB/TrEMBL
      A2A7G6, A2A7G7
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    8. XM_030253791.1XP_030109651.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    9. XM_030253788.2XP_030109648.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      UniProtKB/Swiss-Prot
      Q3TMY6, Q91VP1, Q9D752
      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain
    10. XM_006539189.4XP_006539252.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      See identical proteins and their annotated locations for XP_006539252.1

      UniProtKB/TrEMBL
      A2A7G6, A2A7G7
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    11. XM_030253795.2XP_030109655.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      UniProtKB/TrEMBL
      A2A7G6, A2A7G7
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    12. XM_030253792.2XP_030109652.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    13. XM_030253799.2XP_030109659.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      UniProtKB/TrEMBL
      A2A7G6, A2A7G7
      Related
      ENSMUSP00000101332.2, ENSMUST00000105707.2
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    14. XM_030253796.1XP_030109656.1  mitotic spindle assembly checkpoint protein MAD2B isoform X3

      UniProtKB/TrEMBL
      A2A7G6, A2A7G7
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    15. XM_030253793.2XP_030109653.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    16. XM_006539188.3XP_006539251.1  mitotic spindle assembly checkpoint protein MAD2B isoform X2

      See identical proteins and their annotated locations for XP_006539251.1

      UniProtKB/TrEMBL
      A2A7G6
      Conserved Domains (1) summary
      pfam02301
      Location:18100
      HORMA; HORMA domain
    17. XM_030253790.2XP_030109650.1  mitotic spindle assembly checkpoint protein MAD2B isoform X1

      UniProtKB/Swiss-Prot
      Q3TMY6, Q91VP1, Q9D752
      UniProtKB/TrEMBL
      A2A7G6
      Related
      ENSMUSP00000122774.2, ENSMUST00000132698.8
      Conserved Domains (1) summary
      pfam02301
      Location:18103
      HORMA; HORMA domain

    RNA

    1. XR_004941965.1 RNA Sequence