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    Pdia6 protein disulfide isomerase associated 6 [ Mus musculus (house mouse) ]

    Gene ID: 71853, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pdia6provided by MGI
    Official Full Name
    protein disulfide isomerase associated 6provided by MGI
    Primary source
    MGI:MGI:1919103
    See related
    Ensembl:ENSMUSG00000020571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; P5; CaB; CaBP5; Txndc; C77895; Txndc7; AL023058; 1700015E05Rik
    Expression
    Broad expression in placenta adult (RPKM 219.9), CNS E11.5 (RPKM 121.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Pdia6 in Genome Data Viewer
    Location:
    12; 12 A1.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17316590..17334786)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17266589..17284785)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (17273401..17291576)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36568 Neighboring gene predicted gene 10054 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit C2 Neighboring gene predicted gene, 46336 Neighboring gene nucleolar protein 10 Neighboring gene microRNA 3066

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-disulfide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of IRE1-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    part_of endoplasmic reticulum chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein disulfide-isomerase A6
    Names
    protein disulfide isomerase-related protein
    thioredoxin domain containing 7
    thioredoxin domain-containing protein 7
    NP_082235.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027959.4NP_082235.2  protein disulfide-isomerase A6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC159815
      Consensus CDS
      CCDS25826.1
      Related
      ENSMUSP00000159304.2, ENSMUST00000239402.2
      Conserved Domains (2) summary
      cd02983
      Location:275404
      P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
      cd03001
      Location:26128
      PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      17316590..17334786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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