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    Pdia6 protein disulfide isomerase associated 6 [ Mus musculus (house mouse) ]

    Gene ID: 71853, updated on 9-Sep-2018

    Summary

    Official Symbol
    Pdia6provided by MGI
    Official Full Name
    protein disulfide isomerase associated 6provided by MGI
    Primary source
    MGI:MGI:1919103
    See related
    Ensembl:ENSMUSG00000020571 Vega:OTTMUSG00000023877
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P5; CaBP5; C77895; Txndc7; AL023058; 1700015E05Rik
    Expression
    Broad expression in placenta adult (RPKM 219.9), CNS E11.5 (RPKM 121.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See Pdia6 in Genome Data Viewer
    Location:
    12; 12 A1.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (17266595..17284770)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (17273401..17291576)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36568 Neighboring gene predicted gene 10054 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit C2 Neighboring gene predicted gene, 46336 Neighboring gene nucleolar protein 10 Neighboring gene microRNA 3066

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptide disulfide oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein disulfide-isomerase A6
    Names
    protein disulfide isomerase-related protein
    thioredoxin domain containing 7
    thioredoxin domain-containing protein 7
    NP_082235.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027959.3NP_082235.1  protein disulfide-isomerase A6 precursor

      See identical proteins and their annotated locations for NP_082235.1

      Status: PROVISIONAL

      Source sequence(s)
      AC159815
      Consensus CDS
      CCDS25826.1
      UniProtKB/Swiss-Prot
      Q922R8
      UniProtKB/TrEMBL
      Q3TML0
      Related
      ENSMUSP00000052912.5, OTTMUSP00000028252, ENSMUST00000057288.5, OTTMUST00000058331
      Conserved Domains (2) summary
      cd02983
      Location:280409
      P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
      cd03001
      Location:31133
      PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      17266595..17284770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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