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    Kif23 kinesin family member 23 [ Mus musculus (house mouse) ]

    Gene ID: 71819, updated on 8-Jul-2021

    Summary

    Official Symbol
    Kif23provided by MGI
    Official Full Name
    kinesin family member 23provided by MGI
    Primary source
    MGI:MGI:1919069
    See related
    Ensembl:ENSMUSG00000032254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kn; CHO; MKL; CHO1; MKLP; Knsl5; MKLP1; C87313; MKLP-1; 3110001D19Rik
    Expression
    Biased expression in CNS E11.5 (RPKM 14.9), liver E14 (RPKM 11.3) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kif23 in Genome Data Viewer
    Location:
    9; 9 B
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (61824559..61854087, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (61917277..61946810, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (61765084..61794606, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35058 Neighboring gene ribosomal protein, large, P1 Neighboring gene progestin and adipoQ receptor family member V Neighboring gene predicted gene, 35152 Neighboring gene glucuronyl C5-epimerase Neighboring gene microRNA 5133

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic spindle midzone assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of centralspindlin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF23
    Names
    kinesin-like 5 (mitotic kinesin-like protein 1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024245.4NP_077207.3  kinesin-like protein KIF23

      See identical proteins and their annotated locations for NP_077207.3

      Status: VALIDATED

      Source sequence(s)
      AC151969, AI132370, AK030771, BB688982, BY132148
      Consensus CDS
      CCDS40662.1
      UniProtKB/Swiss-Prot
      E9Q5G3
      Related
      ENSMUSP00000034815.8, ENSMUST00000034815.9
      Conserved Domains (4) summary
      cd01368
      Location:24434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31436
      Kinesin; Kinesin motor domain
      pfam08702
      Location:498603
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam16540
      Location:797896
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      61824559..61854087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244619.2XP_030100479.1  kinesin-like protein KIF23 isoform X5

      Conserved Domains (3) summary
      pfam05483
      Location:490676
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd01368
      Location:24434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:693795
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    2. XM_030244618.2XP_030100478.1  kinesin-like protein KIF23 isoform X4

      Conserved Domains (3) summary
      pfam05483
      Location:504690
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:707809
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    3. XM_006511453.5XP_006511516.1  kinesin-like protein KIF23 isoform X2

      Conserved Domains (3) summary
      pfam05483
      Location:504690
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:811913
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    4. XM_006511452.5XP_006511515.1  kinesin-like protein KIF23 isoform X1

      Conserved Domains (3) summary
      pfam05483
      Location:504690
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:811913
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    5. XM_006511454.5XP_006511517.1  kinesin-like protein KIF23 isoform X3

      Conserved Domains (3) summary
      pfam05483
      Location:504690
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:707809
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
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