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    Ap2b1 adaptor-related protein complex 2, beta 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 71770, updated on 19-Mar-2019

    Summary

    Official Symbol
    Ap2b1provided by MGI
    Official Full Name
    adaptor-related protein complex 2, beta 1 subunitprovided by MGI
    Primary source
    MGI:MGI:1919020
    See related
    Ensembl:ENSMUSG00000035152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP105B; AI788979; 1300012O03Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 73.6), CNS E18 (RPKM 36.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ap2b1 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (83298719..83405035)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (83116199..83218537)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene schlafen 14 Neighboring gene expressed sequence AA465934 Neighboring gene expressed sequence AI450353 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (2)  1 citation
    • Targeted (1) 
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cargo receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    clathrin adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane coat IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-2 complex subunit beta
    Names
    adapter-related protein complex 2 beta subunit
    adapter-related protein complex 2 subunit beta
    adaptor protein complex AP-2 subunit beta
    adaptor-related protein complex 2 subunit beta
    beta-2-adaptin
    beta-adaptin
    beta2-adaptin
    clathrin assembly protein complex 2 beta large chain
    plasma membrane adaptor HA2/AP2 adaptin beta subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035854.2NP_001030931.1  AP-2 complex subunit beta isoform a

      See identical proteins and their annotated locations for NP_001030931.1

      Status: VALIDATED

      Source sequence(s)
      AK138434, AL603711
      Consensus CDS
      CCDS25161.1
      UniProtKB/Swiss-Prot
      Q9DBG3
      UniProtKB/TrEMBL
      Q5SWR1
      Related
      ENSMUSP00000018875.6, ENSMUST00000018875.12
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    2. NM_027915.3NP_082191.1  AP-2 complex subunit beta isoform b

      See identical proteins and their annotated locations for NP_082191.1

      Status: VALIDATED

      Source sequence(s)
      AK004975, AK138434, AL603711
      Consensus CDS
      CCDS25162.1
      UniProtKB/Swiss-Prot
      Q9DBG3
      UniProtKB/TrEMBL
      Q5SWR1
      Related
      ENSMUSP00000070714.7, ENSMUST00000065692.13
      Conserved Domains (4) summary
      smart00809
      Location:717817
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:826936
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      83298719..83405035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314772.1XP_017170261.1  AP-2 complex subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q9DBG3
      UniProtKB/TrEMBL
      Q5SWR1
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    2. XM_006534258.3XP_006534321.1  AP-2 complex subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006534321.1

      UniProtKB/Swiss-Prot
      Q9DBG3
      UniProtKB/TrEMBL
      Q5SWR1
      Related
      ENSMUSP00000135445.1, ENSMUST00000176523.1
      Conserved Domains (4) summary
      smart00809
      Location:731831
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:840950
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
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