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    Tysnd1 trypsin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 71767, updated on 12-Aug-2018

    Summary

    Official Symbol
    Tysnd1provided by MGI
    Official Full Name
    trypsin domain containing 1provided by MGI
    Primary source
    MGI:MGI:1919017
    See related
    Ensembl:ENSMUSG00000020087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300019N10Rik
    Summary
    This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
    Expression
    Broad expression in adrenal adult (RPKM 220.9), duodenum adult (RPKM 66.0) and 18 other tissues See more
    Orthologs

    Genomic context

    See Tysnd1 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (61695498..61702773)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (61158262..61165521)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700022H01 gene Neighboring gene secretion associated Ras related GTPase 1A Neighboring gene apoptosis-inducing factor, mitochondrion-associated 2 Neighboring gene H2A histone family, member Y2 Neighboring gene microRNA 5108

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxisomal leader peptide-processing protease
    Names
    trypsin domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272090.1NP_001259019.1  peroxisomal leader peptide-processing protease isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC153136, AI181257, AK005069
      UniProtKB/Swiss-Prot
      Q9DBA6
      Conserved Domains (2) summary
      pfam13365
      Location:359429
      Trypsin_2; Trypsin-like peptidase domain
      cl21584
      Location:187268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001272091.1NP_001259020.1  peroxisomal leader peptide-processing protease isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC153136, AK005069
      UniProtKB/Swiss-Prot
      Q9DBA6
      Conserved Domains (1) summary
      cl21584
      Location:187268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_001272092.1NP_001259021.1  peroxisomal leader peptide-processing protease isoform d

      See identical proteins and their annotated locations for NP_001259021.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC153136, AK005069
      UniProtKB/Swiss-Prot
      Q9DBA6
      Conserved Domains (2) summary
      pfam13365
      Location:359460
      Trypsin_2; Trypsin-like peptidase domain
      cl21584
      Location:187268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. NM_027912.1NP_082188.1  peroxisomal leader peptide-processing protease isoform a

      See identical proteins and their annotated locations for NP_082188.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC153136, AK005069, AV148467
      Consensus CDS
      CCDS48575.1
      UniProtKB/Swiss-Prot
      Q9DBA6
      Related
      ENSMUSP00000020284.4, ENSMUST00000020284.4
      Conserved Domains (3) summary
      pfam00089
      Location:344528
      Trypsin; Trypsin
      pfam13365
      Location:359498
      Trypsin_2; Trypsin-like peptidase domain
      cl21584
      Location:187268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RNA

    1. NR_073587.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC153136, AK005069, BE847683

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      61695498..61702773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514168.3XP_006514231.1  peroxisomal leader peptide-processing protease isoform X1

      Conserved Domains (1) summary
      cl21584
      Location:187268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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