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    TPP2 tripeptidyl peptidase 2 [ Homo sapiens (human) ]

    Gene ID: 7174, updated on 8-Jul-2021

    Summary

    Official Symbol
    TPP2provided by HGNC
    Official Full Name
    tripeptidyl peptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:12016
    See related
    Ensembl:ENSG00000134900 MIM:190470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IMD78; TPP-2; TPPII; TPP-II
    Summary
    This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 15.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TPP2 in Genome Data Viewer
    Location:
    13q33.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (102596985..102679958)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (103249336..103332308)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 14 Neighboring gene FGF14 antisense RNA 2 Neighboring gene uncharacterized LOC107984588 Neighboring gene methyltransferase 21C, AARS1 lysine Neighboring gene uncharacterized LOC105370337 Neighboring gene coiled-coil domain containing 168 Neighboring gene testis expressed 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ40359

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aminopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tripeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination TAS
    Traceable Author Statement
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    tripeptidyl-peptidase 2
    Names
    tripeptidyl aminopeptidase
    tripeptidyl-peptidase II
    NP_001317517.1
    NP_001354876.1
    NP_003282.2
    XP_005254127.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_063544.1 RefSeqGene

      Range
      5001..87973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1341

    mRNA and Protein(s)

    1. NM_001330588.2NP_001317517.1  tripeptidyl-peptidase 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is longer than isoform 1.
      Source sequence(s)
      AU132468, BC039905, BF514671, BM684792, BX370108, DB303355, M73047, N27441
      Consensus CDS
      CCDS81777.1
      UniProtKB/Swiss-Prot
      P29144
      UniProtKB/TrEMBL
      Q5VZU9
      Related
      ENSP00000365220.3, ENST00000376052.5
      Conserved Domains (2) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam12580
      Location:777960
      TPPII; Tripeptidyl peptidase II
    2. NM_001367947.1NP_001354876.1  tripeptidyl-peptidase 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is longer than isoform 1.
      Source sequence(s)
      AL158063
      Conserved Domains (2) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam12580
      Location:777960
      TPPII; Tripeptidyl peptidase II
    3. NM_003291.4NP_003282.2  tripeptidyl-peptidase 2 isoform 1

      See identical proteins and their annotated locations for NP_003282.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest, but most predominant, isoform (1).
      Source sequence(s)
      AU132468, BC039905, BF514671, BM684792, DB303355, M73047, N27441
      Consensus CDS
      CCDS9502.1
      UniProtKB/Swiss-Prot
      P29144
      Related
      ENSP00000365233.4, ENST00000376065.8
      Conserved Domains (2) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam12580
      Location:777960
      TPPII; Tripeptidyl peptidase II

    RNA

    1. NR_160411.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL158063

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      102596985..102679958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254070.2XP_005254127.1  tripeptidyl-peptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_005254127.1

      Conserved Domains (2) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam12580
      Location:777960
      TPPII; Tripeptidyl peptidase II

    RNA

    1. XR_001749654.2 RNA Sequence

    2. XR_243046.2 RNA Sequence

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