Format

Send to:

Choose Destination
    • Showing Current items.

    Mus81 MUS81 structure-specific endonuclease subunit [ Mus musculus (house mouse) ]

    Gene ID: 71711, updated on 9-Sep-2018

    Summary

    Official Symbol
    Mus81provided by MGI
    Official Full Name
    MUS81 structure-specific endonuclease subunitprovided by MGI
    Primary source
    MGI:MGI:1918961
    See related
    Ensembl:ENSMUSG00000024906 Vega:OTTMUSG00000033940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI182501; AW045863; 1200008A18Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 19.3), cerebellum adult (RPKM 15.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mus81 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (5482836..5488410, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5482840..5488336, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor (acidic) intracellular binding protein Neighboring gene cathepsin W Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Neighboring gene cofilin 1, non-muscle Neighboring gene sorting nexin 32 Neighboring gene RIKEN cDNA 1700020D05 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    3'-flap endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to crossover junction endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA catabolic process, endonucleolytic ISO
    Inferred from Sequence Orthology
    more info
     
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intra-S DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    crossover junction endonuclease MUS81
    Names
    MUS81 endonuclease homolog
    NP_082153.3
    XP_006531901.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027877.4NP_082153.3  crossover junction endonuclease MUS81

      See identical proteins and their annotated locations for NP_082153.3

      Status: VALIDATED

      Source sequence(s)
      AA014278, AC126029, AK004647, AK145858, BY208661
      Consensus CDS
      CCDS29467.1
      UniProtKB/Swiss-Prot
      Q91ZJ0
      Related
      ENSMUSP00000114895.1, OTTMUSP00000046281, ENSMUST00000124334.7
      Conserved Domains (2) summary
      COG1948
      Location:248515
      MUS81; ERCC4-type nuclease [Replication, recombination and repair]
      pfam02732
      Location:273415
      ERCC4; ERCC4 domain

    RNA

    1. NR_153768.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126029, AK145858
    2. NR_153769.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126029

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      5482836..5488410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531838.3XP_006531901.1  crossover junction endonuclease MUS81 isoform X1

      Related
      ENSMUSP00000118580.1, OTTMUSP00000046283, ENSMUST00000133436.7, OTTMUST00000085634
      Conserved Domains (1) summary
      pfam02732
      Location:273415
      ERCC4; ERCC4 domain

    RNA

    1. XR_388271.3 RNA Sequence

      Related
      ENSMUST00000025841.3, OTTMUST00000085632
    2. XR_388272.3 RNA Sequence

    Support Center